Detailed information of TA system TA183560

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 5041607..5042865
• Replicon: chromosome
• Accession: NZ_CP065865
• Organism: Pseudomonas aeruginosa strain TJ2019-022

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: I9X26_RS23840
• Protein ID: WP_003112528.1
• Coordinates: 5041607..5042362 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: I9X26_RS23845
• Protein ID: WP_003086329.1
• Coordinates: 5042497..5042865 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I9X26_RS23830	5036780..5039323	+	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-
I9X26_RS23835	5039478..5040839	-	1362	WP_010895536.1	DNA recombination protein RmuC	-
I9X26_RS23840	5041607..5042362	-	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
I9X26_RS23845	5042497..5042865	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
I9X26_RS23850	5042938..5044224	-	1287	WP_003112529.1	FAD-binding oxidoreductase	-
I9X26_RS23855	5044280..5045869	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
I9X26_RS23860	5045948..5046424	+	477	WP_003112531.1	hypothetical protein	-
I9X26_RS23865	5046427..5046702	-	276	WP_010793902.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T183560 WP_003112528.1 NZ_CP065865:c5042362-5041607 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T183560 NZ_CP087111:c1292164-1291589 [Pseudomonas palleroniana]
ATGAGGTGTTCGCCTTTTACTGCTGTATACGATGCTTGTGTCCTCTACCCGGCGGCTCTTCGGGATTTGCTGATGTGGCT
TGGCTTGTCGGGGCTGTATCGAGCGAGATGGACTAACCAAATTCATGAAGAGTGGAAGCGGAACGTGCTCAAGAACCGAC
CTGATCTCACGGTAGAGCAAGTTAATTGCACGTCGGCCCTGATGGACAAGGCGATACCCGATGCTTTGGTGACGGGATAT
GAGGACCTATGTTCTGGTTTGGATTTGCCTGATCCTGATGATCGCCACGTGCTGGCGGCGGCGATTCGGAGCAAGGCTGA
GGTTATCGTGACCTTCAATTTGAAAGACTTTCCGCCGCATATCCTGGCTGCCTATGATATTGAGCCGATGCATCCGGATG
ACTTTATTTCAGACCTTTGGGATCTGGATCAGGCGGCTGTGTTGGGGGCTGCGCAGAAACAGAGGCGAGCGTTGAAGCGG
CCTCCTATGGAGGCGGGGAATTACATTGAGATGTTGATGCGACAGGGCTTGGTGCAGACTAGTAAGGTTCTTGGGCCTTA
TGAGGTAATGCTTTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT183560 WP_003086329.1 NZ_CP065865:c5042865-5042497 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT183560 NZ_CP087111:c1292631-1292161 [Pseudomonas palleroniana]
ATGATGACTAACCACCTTCCCAAAACGATCCTTCCGCTGGAGAAGGAAGTCGAAGCCGCCGTGCAAGGCCAGCGCGAGCT
AGCGTCTTTGTTGTCGACCAAATTTGAAACCCAGCGCATCGACATTTTCGACAAAGAAGACAAACCCCACACCCTGGTAC
TGCCCACCTCAGCACTGCGCCTGCTGGTCGATATTCTGGGTGAGTTGGCTATTGGCAATGCCGTCAAAGTAGTGCCAGTT
CATGCCGAGTTGACCTCGCAGGAGGCCGCCGACCTGCTTAATGTTTCACGCCCCCATTTGGTCAAGATGCTGGAGGAAGG
TGCTATCCCCTTTACAAAAACGGGTCGTCATCGGCGAATTCGATTTTCGGATTTGATGTCGTTCAAGCAGCGACGTGATG
AAGAAAGCCAAGAGGCAATGGAAGCGCTGGCGCAACAAGCCCAAGAGTTGGGAATGGGGTATGACGGATGA

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7