Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 2505684..2506723 | Replicon | chromosome |
| Accession | NZ_CP065865 | ||
| Organism | Pseudomonas aeruginosa strain TJ2019-022 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | I9X26_RS11845 | Protein ID | WP_155664451.1 |
| Coordinates | 2506148..2506723 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A7L5F0B4 |
| Locus tag | I9X26_RS11840 | Protein ID | WP_043156233.1 |
| Coordinates | 2505684..2506151 (+) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I9X26_RS11795 | 2501331..2502281 | - | 951 | WP_155664467.1 | TIGR03756 family integrating conjugative element protein | - |
| I9X26_RS11800 | 2502278..2502694 | - | 417 | WP_134587217.1 | TIGR03757 family integrating conjugative element protein | - |
| I9X26_RS11805 | 2502802..2503305 | - | 504 | WP_196499173.1 | GNAT family N-acetyltransferase | - |
| I9X26_RS11810 | 2503293..2503583 | - | 291 | WP_134587219.1 | DUF1778 domain-containing protein | - |
| I9X26_RS11815 | 2503637..2504245 | - | 609 | WP_134587220.1 | hypothetical protein | - |
| I9X26_RS11820 | 2504482..2504685 | - | 204 | Protein_2334 | DNA repair protein RadC | - |
| I9X26_RS11825 | 2504682..2504840 | - | 159 | Protein_2335 | TIGR03745 family integrating conjugative element membrane protein | - |
| I9X26_RS11830 | 2504857..2505090 | - | 234 | WP_003050225.1 | TIGR03758 family integrating conjugative element protein | - |
| I9X26_RS11835 | 2505087..2505470 | - | 384 | WP_155664453.1 | RAQPRD family integrative conjugative element protein | - |
| I9X26_RS11840 | 2505684..2506151 | + | 468 | WP_043156233.1 | helix-turn-helix domain-containing protein | Antitoxin |
| I9X26_RS11845 | 2506148..2506723 | + | 576 | WP_155664451.1 | PIN domain-containing protein | Toxin |
| I9X26_RS11850 | 2506741..2507655 | + | 915 | WP_155664449.1 | AAA family ATPase | - |
| I9X26_RS11855 | 2507652..2508122 | + | 471 | WP_155664446.1 | hypothetical protein | - |
| I9X26_RS11860 | 2508119..2508619 | + | 501 | WP_155664444.1 | HORMA domain containing protein | - |
| I9X26_RS11865 | 2508619..2509521 | + | 903 | WP_155664442.1 | nucleotidyltransferase domain-containing protein | - |
| I9X26_RS11870 | 2509558..2510283 | + | 726 | WP_155664440.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2452558..2591259 | 138701 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21590.57 Da Isoelectric Point: 5.6513
>T183558 WP_155664451.1 NZ_CP065865:2506148-2506723 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQTIHEEWKRNLLINRSDLTRAQVDRTSDLMDRAIPDGLVEGY
ESLAAGLTLPDPDDRHVLAAAIRCGASVIVTFNQRDFPNELLAPYGVESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLRN
PTIDVDRYLDILLRQGLVQTTKVLASYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQTIHEEWKRNLLINRSDLTRAQVDRTSDLMDRAIPDGLVEGY
ESLAAGLTLPDPDDRHVLAAAIRCGASVIVTFNQRDFPNELLAPYGVESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLRN
PTIDVDRYLDILLRQGLVQTTKVLASYRTIL
Download Length: 576 bp
>T183558 NZ_CP087110:c4216396-4216223 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 156 a.a. Molecular weight: 17251.62 Da Isoelectric Point: 5.9214
>AT183558 WP_043156233.1 NZ_CP065865:2505684-2506151 [Pseudomonas aeruginosa]
MTVTAQSKMTLPAEGEVKAAVQGQRALAAYLATQFETQHIQIFDDQKQAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELTQQSQELGMGYE
MTVTAQSKMTLPAEGEVKAAVQGQRALAAYLATQFETQHIQIFDDQKQAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELTQQSQELGMGYE
Download Length: 468 bp
>AT183558 NZ_CP087110:c4216720-4216424 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|