Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2502802..2503583 Replicon chromosome
Accession NZ_CP065865
Organism Pseudomonas aeruginosa strain TJ2019-022

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag I9X26_RS11805 Protein ID WP_196499173.1
Coordinates 2502802..2503305 (-) Length 168 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag I9X26_RS11810 Protein ID WP_134587219.1
Coordinates 2503293..2503583 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9X26_RS11780 2498003..2499547 - 1545 WP_134587331.1 conjugal transfer protein TraG N-terminal domain-containing protein -
I9X26_RS11785 2499561..2499929 - 369 WP_196499174.1 hypothetical protein -
I9X26_RS11790 2499926..2501320 - 1395 WP_155664469.1 integrating conjugative element protein -
I9X26_RS11795 2501331..2502281 - 951 WP_155664467.1 TIGR03756 family integrating conjugative element protein -
I9X26_RS11800 2502278..2502694 - 417 WP_134587217.1 TIGR03757 family integrating conjugative element protein -
I9X26_RS11805 2502802..2503305 - 504 WP_196499173.1 GNAT family N-acetyltransferase Toxin
I9X26_RS11810 2503293..2503583 - 291 WP_134587219.1 DUF1778 domain-containing protein Antitoxin
I9X26_RS11815 2503637..2504245 - 609 WP_134587220.1 hypothetical protein -
I9X26_RS11820 2504482..2504685 - 204 Protein_2334 DNA repair protein RadC -
I9X26_RS11825 2504682..2504840 - 159 Protein_2335 TIGR03745 family integrating conjugative element membrane protein -
I9X26_RS11830 2504857..2505090 - 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
I9X26_RS11835 2505087..2505470 - 384 WP_155664453.1 RAQPRD family integrative conjugative element protein -
I9X26_RS11840 2505684..2506151 + 468 WP_043156233.1 helix-turn-helix domain-containing protein -
I9X26_RS11845 2506148..2506723 + 576 WP_155664451.1 PIN domain-containing protein -
I9X26_RS11850 2506741..2507655 + 915 WP_155664449.1 AAA family ATPase -
I9X26_RS11855 2507652..2508122 + 471 WP_155664446.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2452558..2591259 138701


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(47-148)

Antitoxin

Vibrio phage ICP1, Orf50

(1-96)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 17992.78 Da        Isoelectric Point: 9.9548

>T183557 WP_196499173.1 NZ_CP065865:c2503305-2502802 [Pseudomonas aeruginosa]
MGKVMPLSAPQPLAAHHDIQSFSSGVDSLDQWLKRRALKNQTTGASRTFVVCEDKRVLAYYALASSAVISAEASGRFRRN
MPDPIPVVVLGRLAVDQSLQGQGFGRALVQDAGRRVIQAADAIGIRGMLVHALSPEAKAFYERLGFEPSALDPMTLMTTL
ADLKASL

Download         Length: 504 bp

>T183557 NZ_CP087110:c4120612-4120262 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10873.52 Da        Isoelectric Point: 10.2614

>AT183557 WP_134587219.1 NZ_CP065865:c2503583-2503293 [Pseudomonas aeruginosa]
MSTTLNITPGKRETLNLRIKPEERSLIDRAAKVRGKNRTDFVLEAARAAAEEALLDQSIIAVDQEAYAAFLARLDMPPQP
NERLRKTMRTPAPWEK

Download         Length: 291 bp

>AT183557 NZ_CP087110:c4120857-4120606 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References