Detailed information of TA system TA183555

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1566408..1567065
• Replicon: chromosome
• Accession: NZ_CP065865
• Organism: Pseudomonas aeruginosa strain TJ2019-022

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: I9X26_RS07335
• Protein ID: WP_033971890.1
• Coordinates: 1566883..1567065 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: I9X26_RS07330
• Protein ID: WP_003124172.1
• Coordinates: 1566408..1566836 (-)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I9X26_RS07295	1561712..1562467	-	756	WP_041025224.1	helix-turn-helix transcriptional regulator	-
I9X26_RS07300	1563064..1563825	+	762	WP_198340117.1	helix-turn-helix domain-containing protein	-
I9X26_RS07305	1563822..1564505	+	684	WP_198340118.1	replication P family protein	-
I9X26_RS07310	1564502..1564708	+	207	WP_023114601.1	hypothetical protein	-
I9X26_RS07315	1564705..1565286	+	582	WP_021205616.1	recombination protein NinG	-
I9X26_RS07320	1565283..1565579	+	297	WP_043486973.1	hypothetical protein	-
I9X26_RS07325	1565617..1566291	+	675	WP_021205614.1	hypothetical protein	-
I9X26_RS07330	1566408..1566836	-	429	WP_003124172.1	hypothetical protein	Antitoxin
I9X26_RS07335	1566883..1567065	-	183	WP_033971890.1	type II toxin-antitoxin system HicA family toxin	Toxin
I9X26_RS07340	1567266..1567580	+	315	WP_015649339.1	phage holin, lambda family	-
I9X26_RS07345	1567580..1568197	+	618	WP_083557294.1	glycoside hydrolase family 19 protein	-
I9X26_RS07350	1568194..1568436	+	243	WP_024928444.1	hypothetical protein	-
I9X26_RS07355	1568433..1568903	+	471	WP_083557293.1	lysis system i-spanin subunit Rz	-
I9X26_RS07360	1568900..1569643	+	744	WP_003159066.1	hypothetical protein	-
I9X26_RS07365	1569775..1570302	+	528	WP_023117090.1	terminase small subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1538417..1600071	61654

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (7-78)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6776.89 Da
• Isoelectric Point: 11.0775

>T183555 WP_033971890.1 NZ_CP065865:c1567065-1566883 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGTKEMPEPTRKAIIKQLGLK

Nucleotide

• Length: 183 bp

>T183555 NZ_CP087110:3891061-3891318 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 15770.97 Da
• Isoelectric Point: 4.6562

>AT183555 WP_003124172.1 NZ_CP065865:c1566836-1566408 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKAHAISEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KVALWNEMIRRDMRKADLCRLLGIAQIQGDRLVDFLHNTKMEAMENALSALGLRLSVNIEAA

Nucleotide

• Length: 429 bp

>AT183555 NZ_CP087110:3891330-3891875 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA