Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 150879..151384 Replicon chromosome
Accession NZ_CP065865
Organism Pseudomonas aeruginosa strain TJ2019-022

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag I9X26_RS00710 Protein ID WP_003121619.1
Coordinates 150879..151160 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag I9X26_RS00715 Protein ID WP_003112628.1
Coordinates 151157..151384 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I9X26_RS00685 146130..147479 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
I9X26_RS00690 147528..148214 + 687 WP_003083762.1 FadR family transcriptional regulator -
I9X26_RS00695 148315..149049 + 735 WP_003117208.1 GntR family transcriptional regulator -
I9X26_RS00700 149253..149639 + 387 WP_014602345.1 aegerolysin family protein -
I9X26_RS00705 149671..150579 - 909 WP_003083769.1 LysR family transcriptional regulator -
I9X26_RS00710 150879..151160 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
I9X26_RS00715 151157..151384 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
I9X26_RS00720 151560..152180 - 621 WP_003101226.1 hypothetical protein -
I9X26_RS00725 152281..152781 + 501 WP_003112629.1 LEA type 2 family protein -
I9X26_RS00730 152854..153195 + 342 WP_003101229.1 alkylphosphonate utilization protein -
I9X26_RS00735 153277..154704 - 1428 WP_003083784.1 GABA permease -
I9X26_RS00740 154873..156366 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T183554 WP_003121619.1 NZ_CP065865:c151160-150879 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T183554 NZ_CP087110:3845274-3845615 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT183554 WP_003112628.1 NZ_CP065865:c151384-151157 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT183554 NZ_CP087110:c3845279-3845203 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References