Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 868916..869393 Replicon chromosome
Accession NZ_CP065857
Organism Staphylococcus aureus strain CC1153-MRSA

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag I1A60_RS04140 Protein ID WP_000052076.1
Coordinates 868916..869104 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag I1A60_RS04145 Protein ID WP_001059690.1
Coordinates 869133..869393 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I1A60_RS04110 864870..865427 + 558 WP_072468270.1 hypothetical protein -
I1A60_RS04115 865768..866454 + 687 WP_151359670.1 thermonuclease family protein -
I1A60_RS04120 866811..867011 + 201 WP_001059082.1 cold-shock protein -
I1A60_RS04125 867507..867725 - 219 WP_000005876.1 hypothetical protein -
I1A60_RS04130 867787..868071 - 285 WP_072468268.1 hypothetical protein -
I1A60_RS04135 868159..868728 - 570 WP_001106651.1 hypothetical protein -
I1A60_RS04140 868916..869104 - 189 WP_000052076.1 hypothetical protein Toxin
I1A60_RS04145 869133..869393 - 261 WP_001059690.1 hypothetical protein Antitoxin
I1A60_RS04150 869733..869945 + 213 WP_151359669.1 sterile alpha motif-like domain-containing protein -
I1A60_RS04155 869933..870169 - 237 WP_000368687.1 hypothetical protein -
I1A60_RS04160 870393..870974 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
I1A60_RS04165 871047..871664 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
I1A60_RS04170 871819..872313 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
I1A60_RS04175 872712..873134 - 423 WP_151359668.1 organic hydroperoxide resistance protein -
I1A60_RS04180 873282..873998 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T183539 WP_000052076.1 NZ_CP065857:c869104-868916 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T183539 NZ_CP087110:c964624-964295 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT183539 WP_001059690.1 NZ_CP065857:c869393-869133 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT183539 NZ_CP087110:c964962-964645 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References