Detailed information of TA system TA183533

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3793697..3794918
• Replicon: chromosome
• Accession: NZ_CP065848
• Organism: Pseudomonas aeruginosa strain CMC-097

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IAU57_RS18040
• Protein ID: WP_003160088.1
• Coordinates: 3793697..3794275 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IAU57_RS18045
• Protein ID: WP_003088112.1
• Coordinates: 3794364..3794918 (-)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAU57_RS18025	3788973..3790250	+	1278	WP_003122808.1	TolC family protein	-
IAU57_RS18030	3790240..3792411	+	2172	WP_009876279.1	type I secretion system permease/ATPase	-
IAU57_RS18035	3792401..3793588	+	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
IAU57_RS18040	3793697..3794275	-	579	WP_003160088.1	HD domain-containing protein	Toxin
IAU57_RS18045	3794364..3794918	-	555	WP_003088112.1	helix-turn-helix domain-containing protein	Antitoxin
IAU57_RS18050	3795076..3797271	-	2196	WP_031690533.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
IAU57_RS18055	3797276..3797737	-	462	WP_003102736.1	(2Fe-2S)-binding protein	-
IAU57_RS18060	3798068..3798391	+	324	WP_003102734.1	multidrug efflux SMR transporter	-
IAU57_RS18065	3798404..3798802	+	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
IAU57_RS18070	3798799..3799350	-	552	WP_003102727.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21816.65 Da
• Isoelectric Point: 5.1625

>T183533 WP_003160088.1 NZ_CP065848:c3794275-3793697 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Nucleotide

• Length: 579 bp

>T183533 NZ_CP087107:298257-298703 [Methylobacterium sp. NMS14P]
GTGTACCTCGTCGACACCAACGTCCTCTCGGCCGGCGCGCCGACCAAGGCCGTTCCGGCCGTCGAACTGATCGACTGGAT
GGACCGGAACAGCGCCGGGCTCCACCTCTCCGTCGTCACGATCGCCGAGATCGAGGACGGCATCGCGAAGAGCCGCAGGG
AGGGCGCCGCGCGCAAGGCGGAGCGTTTGGCGGAGTGGCTGGAGACCTTGCTGCACCTGTACGCCGCCAAGGTTCTCCCG
ATCGATCTCGCCGTCGCGCGCCACATCGGCGGGTTGTCCGATCTGGCGCGCGGCCAGGGGCACGCACCCGGCTTCGCGGA
CCTCGCGATCGCCGCCACGGCGCGCTGCAACGGCTGGACGGTTCTCACCCGGAATGTGCGGCACTTCGCGCCGCTGGGCG
TTCCCGCGTGCGATCCCTTCGTGGCGCTGCCAGCCGATCGGCGGTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT183533 WP_003088112.1 NZ_CP065848:c3794918-3794364 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT183533 NZ_CP087107:298013-298252 [Methylobacterium sp. NMS14P]
TTGCAGGAGATTCAGCTTCGGGACGCCAAGGCAACGCTGTCGGCCGTCATCGACCAGGCCAAGCAGGGCGAGCCCTCGAT
CATCACGCGTCATGGCCGGCCCGAGGCCGTGCTGCTCAGCTTCGAGGACTGGCAGAGGCTGTCCCGCGTCCCGTCGTTCG
GCCGCCTGCTCATGGCCGCGCCCGTCGCGGCGGACGACCTCCCCTCCCCGTCCGGTGGGCTCAGAAGCTCCGAGCTGTGA