Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 181744..182654 Replicon plasmid p1
Accession NZ_CP065847
Organism Klebsiella quasipneumoniae strain KqPF42

Toxin (Protein)


Gene name - Uniprot ID A0A2A5MBW7
Locus tag I8N77_RS26515 Protein ID WP_023329005.1
Coordinates 181744..182214 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2A5MC16
Locus tag I8N77_RS26520 Protein ID WP_032731962.1
Coordinates 182211..182654 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8N77_RS26495 177428..178396 - 969 WP_022652343.1 IS5-like element IS903B family transposase -
I8N77_RS26500 178480..179055 + 576 WP_032731970.1 cytochrome b/b6 domain-containing protein -
I8N77_RS26510 181374..181633 + 260 Protein_201 hypothetical protein -
I8N77_RS26515 181744..182214 - 471 WP_023329005.1 RES family NAD+ phosphorylase Toxin
I8N77_RS26520 182211..182654 - 444 WP_032731962.1 DUF2384 domain-containing protein Antitoxin
I8N77_RS26525 182776..183463 - 688 Protein_204 DUF4113 domain-containing protein -
I8N77_RS26530 183624..184619 - 996 WP_032731961.1 DUF2891 domain-containing protein -
I8N77_RS26535 184629..185615 - 987 Protein_206 DUF979 domain-containing protein -
I8N77_RS26540 185612..186333 - 722 Protein_207 DUF969 domain-containing protein -
I8N77_RS26545 186532..186870 + 339 WP_032731959.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..223863 223863


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre

(16-147)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17459.70 Da        Isoelectric Point: 4.4829

>T183528 WP_023329005.1 NZ_CP065847:c182214-181744 [Klebsiella quasipneumoniae]
VILYRLTKTKNLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPANWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHSDFYGIVQMAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T183528 NZ_CP087097:10960-11235 [Pseudosulfitobacter pseudonitzschiae]
GTGCCTGACCTTGAATGGAAGGCATTGGCGGTCGCGGACCTGATGGCGATTGTTGACTATATCTCGGATGACAATCCCGA
TGCCGCAATTTCCCTGATGGATGACATTCAAGACAAGGTGCTTGGCCTTCTGACGCATCCCAAATCCGGCCGCCCCGGTA
GGGTGAACGACACGCGAGAGCTGGTGATCCGGCCCAACTATATCGTCGTCTATGCTGAAAACACGGCGGCGGTCACCATT
CTGCGCGTTCTTCATGCGGTGCAGATGTGGCCCTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16424.76 Da        Isoelectric Point: 10.2497

>AT183528 WP_032731962.1 NZ_CP065847:c182654-182211 [Klebsiella quasipneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAALKWLNEPNRALSWKVPADLIASETGAYEVIKLITRLENGVYS

Download         Length: 444 bp

>AT183528 NZ_CP087097:10674-10967 [Pseudosulfitobacter pseudonitzschiae]
ATGTCCGCTCAAACCTCGATGATTCATGTTCGTGTAGATGATCAGCTCAAGGCAAAGGCCACGGATGCCCTGTCCGGTGT
CGGCCTGACGTTGTCGGACGCCGTGCGCATCCTGCTGACCCGCGTGGCAGCAGAGGGTGGCTTGCCCGCAGGGTTGACGG
CAAATCCTGACGCCTACGATGCCTGGTTCCGCGCCAAGGTACAGGACGCATTGGCCGACGCAGCACCGGCCAAGCCGCAC
GATCAGGTGATGCGAGACGCGCGCGCCTTGATCGACGGCAAGCGCGGTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBW7

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MC16

References