Detailed information of TA system TA183525

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4726576..4727089
• Replicon: chromosome
• Accession: NZ_CP065846
• Organism: Klebsiella quasipneumoniae strain KqPF42

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5Q9LKU5
• Locus tag: I8N77_RS22895
• Protein ID: WP_048322786.1
• Coordinates: 4726576..4726857 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: I8N77_RS22900
• Protein ID: WP_048322784.1
• Coordinates: 4726847..4727089 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I8N77_RS22880	4721684..4723339	+	1656	WP_048322789.1	alpha,alpha-phosphotrehalase	-
I8N77_RS22885	4723725..4725863	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
I8N77_RS22890	4726108..4726572	+	465	WP_004206512.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
I8N77_RS22895	4726576..4726857	-	282	WP_048322786.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I8N77_RS22900	4726847..4727089	-	243	WP_048322784.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
I8N77_RS22905	4727167..4729077	-	1911	WP_004206509.1	BglG family transcription antiterminator	-
I8N77_RS22910	4729100..4730251	-	1152	WP_048322779.1	lactonase family protein	-
I8N77_RS22915	4730318..4731058	-	741	WP_048322777.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11013.82 Da
• Isoelectric Point: 10.2849

>T183525 WP_048322786.1 NZ_CP065846:c4726857-4726576 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T183525 NZ_CP087093:76748-77170 [Pseudosulfitobacter pseudonitzschiae]
ATGATCATCCTCGATACGAATGTCATCTGCGAGCTGTTGCGCCCGACCCCGGAGCCCAGGATCGAGCAATGGCTGTCCGC
TCAAGATGGTCTAAACGTCTACCTGACCTCGATATCGGAGGCGGAGCTGCGCTATGGCCTCGCGAACATGGGGAACGGCA
AGCGCCGCGCTGCGCTGATTGACGCCGTAGACCGCATCCTGCGCGAGGACCTCGCCGGGCGCATTCTGCCCTTCGACAGC
GACGCCGCGCAGGCATACGCCTCTATCGCCGCCACTCGTCGCGACGCCGGGCGACCGATTGCCCAGGCCGATTGCCAGAT
CGCATCCATTGCCCACGCCTGTGGCGCCACCGTCGCCACACGCAATACGCCCGACTTCGAGGGTTGCGAGATTGACCTGA
TCAACCCCTGGACAACCGAATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9117.61 Da
• Isoelectric Point: 5.1486

>AT183525 WP_048322784.1 NZ_CP065846:c4727089-4726847 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT183525 NZ_CP087093:76496-76744 [Pseudosulfitobacter pseudonitzschiae]
ATGGCAAGCATTACGATCCGGAACCTTGACGATGACGTGAAGCGGCGCCTTCGCATCCGAGCGGCCGAGCATGGCCGTTC
GATGGAAGAGGAGGCGCGAGAGATCCTGCGCCAAGTCGTTGGCGACGCGAAGCCCAACCATGATCTTGCCGCGGCGATCC
GTGCGCGGGTTGGACCCTTGGGTGGCGTTGAACTTGACCTTCCGCAGCGTGAAGCCATGCATGAGCCGCCCACATTCGAC
CGAGCCTAA

Structures

Toxin

• AlphaFold DB: A0A5Q9LKU5