Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3999053..3999672 Replicon chromosome
Accession NZ_CP065846
Organism Klebsiella quasipneumoniae strain KqPF42

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I8N77_RS19480 Protein ID WP_002892050.1
Coordinates 3999454..3999672 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I8N77_RS19475 Protein ID WP_002892066.1
Coordinates 3999053..3999427 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8N77_RS19465 3994206..3995399 + 1194 WP_167874582.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I8N77_RS19470 3995422..3998568 + 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit -
I8N77_RS19475 3999053..3999427 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I8N77_RS19480 3999454..3999672 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I8N77_RS19485 3999831..4000397 + 567 WP_004204750.1 maltose O-acetyltransferase -
I8N77_RS19490 4000369..4000491 - 123 WP_032426076.1 hypothetical protein -
I8N77_RS19495 4000534..4001004 + 471 WP_004204751.1 YlaC family protein -
I8N77_RS19500 4000973..4002430 - 1458 WP_048323190.1 PLP-dependent aminotransferase family protein -
I8N77_RS19505 4002531..4003229 + 699 WP_017898895.1 GNAT family N-acetyltransferase -
I8N77_RS19510 4003226..4003366 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I8N77_RS19515 4003366..4003629 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T183524 WP_002892050.1 NZ_CP065846:3999454-3999672 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T183524 NZ_CP087091:104465-104731 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT183524 WP_002892066.1 NZ_CP065846:3999053-3999427 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT183524 NZ_CP087091:104217-104468 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References