Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 828288..828945 Replicon chromosome
Accession NZ_CP065846
Organism Klebsiella quasipneumoniae strain KqPF42

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag I8N77_RS04115 Protein ID WP_004205323.1
Coordinates 828535..828945 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I8N77_RS04110 Protein ID WP_002916312.1
Coordinates 828288..828554 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8N77_RS04085 823439..824872 - 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -
I8N77_RS04090 824991..825719 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
I8N77_RS04095 825769..826080 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
I8N77_RS04100 826243..826902 + 660 WP_004205319.1 hemolysin III family protein -
I8N77_RS04105 827059..828042 - 984 WP_048325672.1 tRNA-modifying protein YgfZ -
I8N77_RS04110 828288..828554 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I8N77_RS04115 828535..828945 + 411 WP_004205323.1 protein YgfX Toxin
I8N77_RS04120 828952..829473 - 522 WP_048325670.1 flavodoxin FldB -
I8N77_RS04125 829574..830470 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I8N77_RS04130 830493..831206 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I8N77_RS04135 831212..832945 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T183514 WP_004205323.1 NZ_CP065846:828535-828945 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T183514 NZ_CP087083:3778252-3778506 [Pseudosulfitobacter pseudonitzschiae]
ATGAACAGCAAGCAGCGGAAAACACTCAAGGCGATTTTCACCGATCCGGTGTCTGGCACAATCGAATGGGTCAGGATCGA
AAGTCTCCTTGTCGCGGCTGGCGCTGAAACCATCGAAGGCAACGGCTCGCGCGTTCGCTTTGTTAAGGACGGCGTGGTTG
GATCGTTCCACCGCCCGCACCCTGACAAAGAGGCAAAGCGCTATCAGGTTAGAGACGCCCGCGCCTTCCTAACGCAGATT
GGAGTAACGCCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT183514 WP_002916312.1 NZ_CP065846:828288-828554 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT183514 NZ_CP087083:3778503-3778832 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCACCATGACTTTCAAAGGCTATCAGGCCCGTGTGGAGTTCGATCCAGAGGACGAGATTTTCTTCGGTAGAATTGC
CGGGATAAACGATGTGGTTGGCTTCCACGGCGAAAGCGTTGCCGAGCTTAAGAGTGCCTTTCATGAAGCCGTTGATGATT
ATCTTGAAACCTGCAAGGCGGCTGGCAAGAAGCCCCAGAAGCCGTATTCTGGCAAGGTGATGTTTCGAGTCGCTCCTGAA
ACCCACAGGCGCATCGCAGTTGCAGCTGAACTTTCCGGCAAGAGCCTGAACCAGTGGGCAGAAGAAAAGCTAGAGGCTGC
TGCCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References