Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 166966..167492 Replicon plasmid p1
Accession NZ_CP065842
Organism Klebsiella quasipneumoniae strain KqPF9

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag I8N79_RS26445 Protein ID WP_000323025.1
Coordinates 166966..167253 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag I8N79_RS26450 Protein ID WP_004196370.1
Coordinates 167253..167492 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8N79_RS26415 162009..162242 - 234 WP_004196327.1 hypothetical protein -
I8N79_RS26420 162321..162668 - 348 WP_004196344.1 hypothetical protein -
I8N79_RS26425 162824..163891 - 1068 WP_004181903.1 hypothetical protein -
I8N79_RS26430 164581..164958 + 378 WP_004196351.1 hypothetical protein -
I8N79_RS26435 165156..166130 - 975 WP_004196336.1 hypothetical protein -
I8N79_RS26440 166736..166894 - 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
I8N79_RS26445 166966..167253 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
I8N79_RS26450 167253..167492 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
I8N79_RS26455 167743..168108 + 366 WP_009651956.1 hypothetical protein -
I8N79_RS26460 168152..168889 + 738 WP_008460272.1 HupE/UreJ family protein -
I8N79_RS26465 168903..169592 + 690 WP_004196322.1 hypothetical protein -
I8N79_RS26470 169623..170999 - 1377 WP_004196363.1 chromate efflux transporter -
I8N79_RS26475 170956..171933 - 978 WP_004196334.1 chromate resistance protein -
I8N79_RS26480 171963..172155 + 193 Protein_170 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..399394 399394


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T183511 WP_000323025.1 NZ_CP065842:c167253-166966 [Klebsiella quasipneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T183511 NZ_CP087081:6744-6995 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTACTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCTATCCACGACAAGCAGGAAGT
TGTCGTGACGCGCAAGAAGGGCGAGTCCGTTGTGGTCGTGTCCTTGGACACTTGGAACGCCGTCAACGAGACTTTGCACC
TGTTGTCCACACCGAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGAGCGTGAG
CTGACCGAGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT183511 WP_004196370.1 NZ_CP065842:c167492-167253 [Klebsiella quasipneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT183511 NZ_CP087081:6992-7258 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGCTGGTTTTTTCGGATCAGGCCTGGGAAGATTATCAGTACTGGGTCAGCACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAATGCAAACGGACCCCCTTCAAAGGTTCCGGCTTGCCGGAACCTTTGAAGGGGGATTTGACAG
GCTGGTGGTCACGGCGAATTTCTCAGGAAGATCGAATGGTTTACCGGGTCAGTGGAACTGGCGACGGCCAAAGCTTAGAG
ATTGCGCAACTTCGGTTTCATTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References