Detailed information of TA system TA183510

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4721889..4722402
• Replicon: chromosome
• Accession: NZ_CP065841
• Organism: Klebsiella quasipneumoniae strain KqPF9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I8N79_RS23040
• Protein ID: WP_124989011.1
• Coordinates: 4721889..4722170 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: I8N79_RS23045
• Protein ID: WP_002886901.1
• Coordinates: 4722160..4722402 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I8N79_RS23025	4716931..4718586	+	1656	WP_048322789.1	alpha,alpha-phosphotrehalase	-
I8N79_RS23030	4718972..4721110	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
I8N79_RS23035	4721421..4721885	+	465	WP_032456904.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
I8N79_RS23040	4721889..4722170	-	282	WP_124989011.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I8N79_RS23045	4722160..4722402	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
I8N79_RS23050	4722480..4724390	-	1911	WP_094311854.1	BglG family transcription antiterminator	-
I8N79_RS23055	4724413..4725564	-	1152	WP_049092410.1	lactonase family protein	-
I8N79_RS23060	4725631..4726371	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10992.75 Da
• Isoelectric Point: 10.2278

>T183510 WP_124989011.1 NZ_CP065841:c4722170-4721889 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLNDLPDCDKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T183510 NZ_CP087080:64266-64541 [Pseudosulfitobacter pseudonitzschiae]
GTGCCTGACCTTGAATGGAAGGCATTGGCGGTCGCGGACCTGATGGCGATTGTTGACTATATCTCGGATGACAATCCCGA
TGCCGCAATTTCCCTGATGGATGACATTCAAGACAAGGTGCTTGGCCTTCTGACGCATCCCAAATCCGGCCGCCCCGGTA
GGGTGAACGACACGCGAGAGCTGGTGATCCGGCCCAACTATATCGTCGTCTATGCTGAAAACACGGCGGCGGTCACCATT
CTGCGCGTTCTTCATGCGGTGCAGATGTGGCCCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT183510 WP_002886901.1 NZ_CP065841:c4722402-4722160 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT183510 NZ_CP087080:63980-64273 [Pseudosulfitobacter pseudonitzschiae]
ATGTCCGCTCAAACCTCGATGATTCATGTTCGTGTAGATGATCAGCTCAAGGCAAAGGCCACGGATGCCCTGTCCGGTGT
CGGCCTGACGTTGTCGGACGCCGTGCGCATCCTGCTGACCCGCGTGGCAGCAGAGGGTGGCTTGCCCGCAGGGTTGACGG
CAAATCCTGACGCCTACGATGCCTGGTTCCGCGCCAAGGTACAGGACGCATTGGCCGACGCAGCACCGGCCAAGCCGCAC
GATCAGGTGATGCGAGACGCGCGCGCCTTGATCGACGGCAAGCGCGGTGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0