Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4002034..4002653 Replicon chromosome
Accession NZ_CP065841
Organism Klebsiella quasipneumoniae strain KqPF9

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I8N79_RS19650 Protein ID WP_002892050.1
Coordinates 4002435..4002653 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I8N79_RS19645 Protein ID WP_002892066.1
Coordinates 4002034..4002408 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8N79_RS19635 3997187..3998380 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I8N79_RS19640 3998403..4001549 + 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit -
I8N79_RS19645 4002034..4002408 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I8N79_RS19650 4002435..4002653 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I8N79_RS19655 4002812..4003378 + 567 WP_004204750.1 maltose O-acetyltransferase -
I8N79_RS19660 4003350..4003472 - 123 WP_032431198.1 hypothetical protein -
I8N79_RS19665 4003515..4003985 + 471 WP_004204751.1 YlaC family protein -
I8N79_RS19670 4003954..4005411 - 1458 WP_064150583.1 PLP-dependent aminotransferase family protein -
I8N79_RS19675 4005512..4006210 + 699 WP_060656954.1 GNAT family N-acetyltransferase -
I8N79_RS19680 4006207..4006347 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I8N79_RS19685 4006347..4006610 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T183509 WP_002892050.1 NZ_CP065841:4002435-4002653 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T183509 NZ_CP087077:c176963-176712 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT183509 WP_002892066.1 NZ_CP065841:4002034-4002408 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT183509 NZ_CP087077:c176715-176449 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References