Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2707810..2709398 Replicon chromosome
Accession NZ_CP065841
Organism Klebsiella quasipneumoniae strain KqPF9

Toxin (Protein)


Gene name hipA Uniprot ID A0A246AZS4
Locus tag I8N79_RS13445 Protein ID WP_017900381.1
Coordinates 2707810..2709132 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2A5MFC9
Locus tag I8N79_RS13450 Protein ID WP_004205921.1
Coordinates 2709132..2709398 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8N79_RS13410 2702892..2703110 + 219 WP_002904808.1 ParD-like family protein -
I8N79_RS13415 2703091..2703873 + 783 WP_064183715.1 type I methionyl aminopeptidase -
I8N79_RS13420 2704142..2705257 + 1116 WP_064183714.1 serine hydrolase -
I8N79_RS13425 2705244..2705588 + 345 WP_004205915.1 hypothetical protein -
I8N79_RS13430 2705617..2706150 + 534 WP_004205916.1 hypothetical protein -
I8N79_RS13435 2706153..2706359 + 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
I8N79_RS13440 2706501..2707793 + 1293 WP_023318214.1 glycoside hydrolase family 10 protein -
I8N79_RS13445 2707810..2709132 - 1323 WP_017900381.1 type II toxin-antitoxin system HipA family toxin Toxin
I8N79_RS13450 2709132..2709398 - 267 WP_004205921.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
I8N79_RS13455 2709681..2710007 - 327 WP_017900379.1 hydroxyisourate hydrolase -
I8N79_RS13460 2710004..2710504 - 501 WP_198072796.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
I8N79_RS13465 2710482..2711861 - 1380 WP_017900377.1 purine permease -
I8N79_RS13470 2712207..2713361 + 1155 WP_004205928.1 FAD-dependent urate hydroxylase HpxO -
I8N79_RS13475 2713342..2714265 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49041.33 Da        Isoelectric Point: 8.6091

>T183508 WP_017900381.1 NZ_CP065841:c2709132-2707810 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARRTLPSDFSAHVWRAITENMLKLHARLQQGLQAG

Download         Length: 1323 bp

>T183508 NZ_CP087077:c176715-176449 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9940.38 Da        Isoelectric Point: 7.1997

>AT183508 WP_004205921.1 NZ_CP065841:c2709398-2709132 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Download         Length: 267 bp

>AT183508 NZ_CP087077:c176963-176712 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246AZS4

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MFC9

References