Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 799411..800186 Replicon chromosome
Accession NZ_CP065841
Organism Klebsiella quasipneumoniae strain KqPF9

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag I8N79_RS04050 Protein ID WP_049092700.1
Coordinates 799701..800186 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag I8N79_RS04045 Protein ID WP_049092701.1
Coordinates 799411..799704 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8N79_RS04025 794614..795216 - 603 WP_004205201.1 short chain dehydrogenase -
I8N79_RS04030 795314..796225 + 912 WP_004205200.1 LysR family transcriptional regulator -
I8N79_RS04035 796226..797374 - 1149 WP_004205199.1 PLP-dependent aspartate aminotransferase family protein -
I8N79_RS04040 797385..798761 - 1377 WP_072500772.1 cystathionine beta-synthase -
I8N79_RS04045 799411..799704 + 294 WP_049092701.1 DUF1778 domain-containing protein Antitoxin
I8N79_RS04050 799701..800186 + 486 WP_049092700.1 GNAT family N-acetyltransferase Toxin
I8N79_RS04055 800365..800817 - 453 WP_049014234.1 hypothetical protein -
I8N79_RS04060 800902..801150 - 249 WP_075205464.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17471.39 Da        Isoelectric Point: 8.1467

>T183498 WP_049092700.1 NZ_CP065841:799701-800186 [Klebsiella quasipneumoniae]
MISAPEPLHTGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPIDPMMLMVTLGDLVN
A

Download         Length: 486 bp

>T183498 NZ_CP087070:c189710-189444 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10972.58 Da        Isoelectric Point: 8.6141

>AT183498 WP_049092701.1 NZ_CP065841:799411-799704 [Klebsiella quasipneumoniae]
MPAANSMTMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIILADPQAYQEFLARLDQAPEPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT183498 NZ_CP087070:c189958-189707 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References