Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 40907..41643 Replicon plasmid p1
Accession NZ_CP065839
Organism Klebsiella quasipneumoniae strain KqPF26

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag I8N75_RS25515 Protein ID WP_074384329.1
Coordinates 41161..41643 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag I8N75_RS25510 Protein ID WP_032415032.1
Coordinates 40907..41173 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8N75_RS25475 36751..37113 - 363 WP_004206665.1 arsenite efflux transporter metallochaperone ArsD -
I8N75_RS25480 37165..37515 - 351 WP_004206664.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
I8N75_RS25485 37873..38121 + 249 WP_004193994.1 hypothetical protein -
I8N75_RS25490 38118..39329 + 1212 WP_032415728.1 hypothetical protein -
I8N75_RS25495 39463..39954 + 492 WP_004206662.1 hypothetical protein -
I8N75_RS25500 40015..40218 + 204 WP_004206661.1 hemolysin expression modulator Hha -
I8N75_RS25505 40232..40462 + 231 WP_004206660.1 hypothetical protein -
I8N75_RS25510 40907..41173 + 267 WP_032415032.1 DUF1778 domain-containing protein Antitoxin
I8N75_RS25515 41161..41643 + 483 WP_074384329.1 GNAT family N-acetyltransferase Toxin
I8N75_RS25520 42073..43785 - 1713 WP_038992633.1 ROK family protein -
I8N75_RS25525 44068..45084 + 1017 WP_038992636.1 hypothetical protein -
I8N75_RS25530 45081..46013 + 933 WP_038992638.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..144959 144959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-148)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17317.04 Da        Isoelectric Point: 10.0704

>T183495 WP_074384329.1 NZ_CP065839:41161-41643 [Klebsiella quasipneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGLKSSQTHERTLFLKLP

Download         Length: 483 bp

>T183495 NZ_CP087066:1337348-1337602 [Pseudosulfitobacter pseudonitzschiae]
ATGAACAGCAAGCAGCGGAAAACACTCAAGGCGATTTTCACCGATCCGGTGTCTGGCACAATCGAATGGGTCAGGATCGA
AAGTCTCCTTGTCGCGGCTGGCGCTGAAACCATCGAAGGCAACGGCTCGCGCGTTCGCTTTGTTAAGGACGGCGTGGTTG
GATCGTTCCACCGCCCGCACCCTGACAAAGAGGCAAAGCGCTATCAGGTTAGAGACGCCCGCGCCTTCCTAACGCAGATT
GGAGTAACGCCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10123.53 Da        Isoelectric Point: 4.5141

>AT183495 WP_032415032.1 NZ_CP065839:40907-41173 [Klebsiella quasipneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT183495 NZ_CP087066:1337599-1337928 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCACCATGACTTTCAAAGGCTATCAGGCCCGTGTGGAGTTCGATCCAGAGGACGAGATTTTCTTCGGTAGAATTGC
CGGGATAAACGATGTGGTTGGCTTCCACGGCGAAAGCGTTGCCGAGCTTAAGAGTGCCTTTCATGAAGCCGTTGATGATT
ATCTTGAAACCTGCAAGGCGGCTGGCAAGAAGCCCCAGAAGCCGTATTCTGGCAAGGTGATGTTTCGAGTCGCTCCTGAA
ACCCACAGGCGCATCGCAGTTGCAGCTGAACTTTCCGGCAAGAGCCTGAACCAGTGGGCAGAAGAAAAGCTAGAGGCTGC
TGCCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References