Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3970386..3971005 Replicon chromosome
Accession NZ_CP065838
Organism Klebsiella quasipneumoniae strain KqPF26

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I8N75_RS19335 Protein ID WP_002892050.1
Coordinates 3970787..3971005 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I8N75_RS19330 Protein ID WP_002892066.1
Coordinates 3970386..3970760 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8N75_RS19320 3965539..3966732 + 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I8N75_RS19325 3966755..3969901 + 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit -
I8N75_RS19330 3970386..3970760 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I8N75_RS19335 3970787..3971005 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I8N75_RS19340 3971163..3971729 + 567 WP_064187828.1 maltose O-acetyltransferase -
I8N75_RS19345 3971701..3971823 - 123 WP_032426076.1 hypothetical protein -
I8N75_RS19350 3971866..3972336 + 471 WP_004204751.1 YlaC family protein -
I8N75_RS19355 3972305..3973762 - 1458 WP_094309518.1 PLP-dependent aminotransferase family protein -
I8N75_RS19360 3973863..3974561 + 699 WP_004204753.1 GNAT family N-acetyltransferase -
I8N75_RS19365 3974558..3974698 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I8N75_RS19370 3974698..3974961 - 264 WP_004204754.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T183492 WP_002892050.1 NZ_CP065838:3970787-3971005 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T183492 NZ_CP087063:227751-228002 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT183492 WP_002892066.1 NZ_CP065838:3970386-3970760 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT183492 NZ_CP087063:227999-228265 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References