Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2576034..2577622 Replicon chromosome
Accession NZ_CP065838
Organism Klebsiella quasipneumoniae strain KqPF26

Toxin (Protein)


Gene name hipA Uniprot ID A0A5Q9LEV0
Locus tag I8N75_RS12545 Protein ID WP_043519554.1
Coordinates 2576034..2577356 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2A5MFC9
Locus tag I8N75_RS12550 Protein ID WP_004205921.1
Coordinates 2577356..2577622 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8N75_RS12510 2571116..2571334 + 219 WP_002904808.1 ParD-like family protein -
I8N75_RS12515 2571315..2572097 + 783 WP_049093365.1 type I methionyl aminopeptidase -
I8N75_RS12520 2572366..2573481 + 1116 WP_094309680.1 serine hydrolase -
I8N75_RS12525 2573468..2573812 + 345 WP_004205915.1 hypothetical protein -
I8N75_RS12530 2573841..2574374 + 534 WP_053810394.1 hypothetical protein -
I8N75_RS12535 2574377..2574583 + 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
I8N75_RS12540 2574725..2576017 + 1293 WP_023318214.1 glycoside hydrolase family 10 protein -
I8N75_RS12545 2576034..2577356 - 1323 WP_043519554.1 type II toxin-antitoxin system HipA family toxin Toxin
I8N75_RS12550 2577356..2577622 - 267 WP_004205921.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
I8N75_RS12555 2577905..2578231 - 327 WP_049003664.1 hydroxyisourate hydrolase -
I8N75_RS12560 2578228..2578728 - 501 WP_017900378.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
I8N75_RS12565 2578706..2580085 - 1380 WP_017900377.1 purine permease -
I8N75_RS12570 2580431..2581585 + 1155 WP_004205928.1 FAD-dependent urate hydroxylase HpxO -
I8N75_RS12575 2581566..2582489 - 924 WP_004205929.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48998.30 Da        Isoelectric Point: 8.2655

>T183490 WP_043519554.1 NZ_CP065838:c2577356-2576034 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLLAG

Download         Length: 1323 bp

>T183490 NZ_CP087060:106740-107135 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCGTTGAGTTCGCGGACACGAATGTCGTTCTTTACCTGCTCGACGACGGCCCAAAGGCCGATCGCGCCGAGGTCAT
CCTGGGGCAGGGGCCCCGGATCAGCGTTCAGGTTCTAAACGAGTCACTGGTGAACTGCCGCCGCAAAGCTGGCCTCGGTT
GGGAGGAAGCAGCGGCCTTTCTCGAAGGCGTGCGCGCCTTGTGTCCCGTCGAAGATCTCACCGTGCAGACCCATGACGTC
GGCCGCGCTTTGGCGGAACGCTACGGCTTCTCGATCTACGACGCGATGATCGTGGCCAGCGCTTTGGTTGCGGGGTGTAC
CACGCTGTGGAGCGAGGACATGCAAGATGGCCTGCTGGTGGAAGGCCAGCTTCGCATCGTCAACCCCTTTGCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9940.38 Da        Isoelectric Point: 7.1997

>AT183490 WP_004205921.1 NZ_CP065838:c2577622-2577356 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Download         Length: 267 bp

>AT183490 NZ_CP087060:106523-106750 [Pseudosulfitobacter pseudonitzschiae]
ATGCAGGTCGCAAAATGGGGTAACTCGCTGGCCGTCCGTTTGCCCGCGGAGCTCGTCCGAGAGCTTGGTCTCAAGGAGGG
TGATCAGATCGACCTGGTCAAGGACGACGGTCGGGTCAGAGTCCGTCGCCTTGCTCGTGCGGATGAGGTACTTACCGGCC
TGCGCCGCTTCCGGGGCAAGTTGTCCGCAGCAGAACGTCTGAGCCGCGACGACGCACATGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LEV0

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MFC9

References