Detailed information of TA system TA183473

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4709451..4711132
• Replicon: chromosome
• Accession: NZ_CP065833
• Organism: Klebsiella pneumoniae strain KpC5

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: I8N78_RS23135
• Protein ID: WP_004146663.1
• Coordinates: 4709451..4710368 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: I8N78_RS23140
• Protein ID: WP_122051607.1
• Coordinates: 4710374..4711132 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I8N78_RS23115	4704757..4706277	+	1521	WP_122051606.1	sugar ABC transporter ATP-binding protein	-
I8N78_RS23120	4706274..4707272	+	999	WP_002885172.1	ribose ABC transporter permease	-
I8N78_RS23125	4707303..4708244	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
I8N78_RS23130	4708319..4709326	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
I8N78_RS23135	4709451..4710368	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I8N78_RS23140	4710374..4711132	-	759	WP_122051607.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
I8N78_RS23145	4711218..4711946	-	729	WP_023288135.1	response regulator transcription factor	-
I8N78_RS23150	4712219..4714366	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
I8N78_RS23155	4714363..4714506	-	144	WP_162992563.1	hypothetical protein	-
I8N78_RS23160	4714712..4715398	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (2-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T183473 WP_004146663.1 NZ_CP065833:c4710368-4709451 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T183473 NZ_CP087042:2461262-2461525 [Pseudosulfitobacter pseudonitzschiae]
ATGAAGTTCGAGTATGACCCTGACAAGAGTGCCGGGAACAAGGCCAAGCACGGCATCGACTTCGATGAAGCGCAAGCGCT
TTGGGAAGACCCGTGGCTGTTGGAGGCTCCCGCTCGAACAGATGACGAGCCGCGCTTTTTTGCAATAGGCATGATCAAGG
AACGGCATTGGTCAGCAGTTTGCACCTATCGCGGTGATATTATTCGGATCATCTCGGTGCGCCGCGCCAGAAAACAGGAG
ATTGAGCACTATGAAAGCACGTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28576.98 Da
• Isoelectric Point: 10.0870

>AT183473 WP_122051607.1 NZ_CP065833:c4711132-4710374 [Klebsiella pneumoniae]
MVTKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT183473 NZ_CP087042:2461512-2461727 [Pseudosulfitobacter pseudonitzschiae]
ATGAAAGCACGTGAGTTCGATCAAAAATTTGACACAGGTGAGAACGTCAGCGATCTTGTGGACTGGTCCAAAGCTAGGCG
GACGAATACCCAGACGAAGCGAGTCAATGTGGATTTTCCGTCGTGGGTCGTTTCTGGTTTGGATCAGAAGGCAAAGCAGC
TCGGCGTTACTCGTCAGTCGCTCATCAAACTCTGGATCGCCGAGCGGCTCCAATGA

Structures

Toxin

• AlphaFold DB: J2XCI1