Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | kacAT/DUF1778(antitoxin) |
Location | 4805646..4806456 | Replicon | chromosome |
Accession | NZ_CP065831 | ||
Organism | Klebsiella pneumoniae strain KpC11 |
Toxin (Protein)
Gene name | KacT | Uniprot ID | - |
Locus tag | I8N76_RS23785 | Protein ID | WP_048299784.1 |
Coordinates | 4805646..4806179 (-) | Length | 178 a.a. |
Antitoxin (Protein)
Gene name | KacA | Uniprot ID | J2E9Q7 |
Locus tag | I8N76_RS23790 | Protein ID | WP_002887278.1 |
Coordinates | 4806190..4806456 (-) | Length | 89 a.a. |
Genomic Context
Location: 4804477..4805598 (1122 bp)
Type: Others
Protein ID: WP_004214138.1
Type: Others
Protein ID: WP_004214138.1
Location: 4808837..4810222 (1386 bp)
Type: Others
Protein ID: WP_040089708.1
Type: Others
Protein ID: WP_040089708.1
Location: 4810240..4810584 (345 bp)
Type: Others
Protein ID: WP_023287080.1
Type: Others
Protein ID: WP_023287080.1
Location: 4805646..4806179 (534 bp)
Type: Toxin
Protein ID: WP_048299784.1
Type: Toxin
Protein ID: WP_048299784.1
Location: 4806190..4806456 (267 bp)
Type: Antitoxin
Protein ID: WP_002887278.1
Type: Antitoxin
Protein ID: WP_002887278.1
Location: 4806559..4807992 (1434 bp)
Type: Others
Protein ID: WP_002887275.1
Type: Others
Protein ID: WP_002887275.1
Location: 4807982..4808665 (684 bp)
Type: Others
Protein ID: WP_002887273.1
Type: Others
Protein ID: WP_002887273.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I8N76_RS23780 | 4804477..4805598 | + | 1122 | WP_004214138.1 | cupin domain-containing protein | - |
I8N76_RS23785 | 4805646..4806179 | - | 534 | WP_048299784.1 | GNAT family N-acetyltransferase | Toxin |
I8N76_RS23790 | 4806190..4806456 | - | 267 | WP_002887278.1 | DUF1778 domain-containing protein | Antitoxin |
I8N76_RS23795 | 4806559..4807992 | - | 1434 | WP_002887275.1 | Cu(+)/Ag(+) sensor histidine kinase | - |
I8N76_RS23800 | 4807982..4808665 | - | 684 | WP_002887273.1 | copper response regulator transcription factor CusR | - |
I8N76_RS23805 | 4808837..4810222 | + | 1386 | WP_040089708.1 | efflux transporter outer membrane subunit | - |
I8N76_RS23810 | 4810240..4810584 | + | 345 | WP_023287080.1 | cation efflux system protein CusF | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 178 a.a. Molecular weight: 19826.65 Da Isoelectric Point: 5.2614
>T183452 WP_048299784.1 NZ_CP065831:c4806179-4805646 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGYDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES
MEQQLTIEMIADAFSYDITGYDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES
Download Length: 534 bp
>T183452 NZ_CP087021:13247-13498 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTACTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCTATCCACGACAAGCAGGAAGT
TGTCGTGACGCGCAAGAAGGGCGAGTCCGTTGTGGTCGTGTCCTTGGACACTTGGAACGCCGTCAACGAGACTTTGCACC
TGTTGTCCACACCGAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGAGCGTGAG
CTGACCGAGTGA
ATGGATGTTATGACCTACTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCTATCCACGACAAGCAGGAAGT
TGTCGTGACGCGCAAGAAGGGCGAGTCCGTTGTGGTCGTGTCCTTGGACACTTGGAACGCCGTCAACGAGACTTTGCACC
TGTTGTCCACACCGAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGAGCGTGAG
CTGACCGAGTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9996.46 Da Isoelectric Point: 10.1757
>AT183452 WP_002887278.1 NZ_CP065831:c4806456-4806190 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR
Download Length: 267 bp
>AT183452 NZ_CP087021:13495-13761 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGCTGGTTTTTTCGGATCAGGCCTGGGAAGATTATCAGTACTGGGTCAGCACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAATGCAAACGGACCCCCTTCAAAGGTTCCGGCTTGCCGGAACCTTTGAAGGGGGATTTGACAG
GCTGGTGGTCACGGCGAATTTCTCAGGAAGATCGAATGGTTTACCGGGTCAGTGGAACTGGCGACGGCCAAAGCTTAGAG
ATTGCGCAACTTCGGTTTCATTACTGA
GTGAAGCTGGTTTTTTCGGATCAGGCCTGGGAAGATTATCAGTACTGGGTCAGCACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAATGCAAACGGACCCCCTTCAAAGGTTCCGGCTTGCCGGAACCTTTGAAGGGGGATTTGACAG
GCTGGTGGTCACGGCGAATTTCTCAGGAAGATCGAATGGTTTACCGGGTCAGTGGAACTGGCGACGGCCAAAGCTTAGAG
ATTGCGCAACTTCGGTTTCATTACTGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
No matching records found |
Antitoxin
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Source | ID | Structure |
---|---|---|
PDB | 5ZGN | |
AlphaFold DB | A0A0H3GLZ1 |