Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4805646..4806456 Replicon chromosome
Accession NZ_CP065831
Organism Klebsiella pneumoniae strain KpC11

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag I8N76_RS23785 Protein ID WP_048299784.1
Coordinates 4805646..4806179 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag I8N76_RS23790 Protein ID WP_002887278.1
Coordinates 4806190..4806456 (-) Length 89 a.a.

Genomic Context


I8N76_RS23780I8N76_RS23805I8N76_RS23810I8N76_RS23785I8N76_RS23790I8N76_RS23795I8N76_RS23800
Location: 4804477..4805598 (1122 bp)
Type: Others
Protein ID: WP_004214138.1
Location: 4808837..4810222 (1386 bp)
Type: Others
Protein ID: WP_040089708.1
Location: 4810240..4810584 (345 bp)
Type: Others
Protein ID: WP_023287080.1
Location: 4805646..4806179 (534 bp)
Type: Toxin
Protein ID: WP_048299784.1
Location: 4806190..4806456 (267 bp)
Type: Antitoxin
Protein ID: WP_002887278.1
Location: 4806559..4807992 (1434 bp)
Type: Others
Protein ID: WP_002887275.1
Location: 4807982..4808665 (684 bp)
Type: Others
Protein ID: WP_002887273.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I8N76_RS237804804477..4805598+1122WP_004214138.1cupin domain-containing protein-
I8N76_RS237854805646..4806179-534WP_048299784.1GNAT family N-acetyltransferaseToxin
I8N76_RS237904806190..4806456-267WP_002887278.1DUF1778 domain-containing proteinAntitoxin
I8N76_RS237954806559..4807992-1434WP_002887275.1Cu(+)/Ag(+) sensor histidine kinase-
I8N76_RS238004807982..4808665-684WP_002887273.1copper response regulator transcription factor CusR-
I8N76_RS238054808837..4810222+1386WP_040089708.1efflux transporter outer membrane subunit-
I8N76_RS238104810240..4810584+345WP_023287080.1cation efflux system protein CusF-

Associated MGEs


Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(91-151)

Antitoxin

(2-86)


Sequences


Toxin        


Download         Length: 178 a.a.        Molecular weight: 19826.65 Da        Isoelectric Point: 5.2614

>T183452 WP_048299784.1 NZ_CP065831:c4806179-4805646 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGYDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T183452 NZ_CP087021:13247-13498 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTACTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCTATCCACGACAAGCAGGAAGT
TGTCGTGACGCGCAAGAAGGGCGAGTCCGTTGTGGTCGTGTCCTTGGACACTTGGAACGCCGTCAACGAGACTTTGCACC
TGTTGTCCACACCGAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGAGCGTGAG
CTGACCGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT183452 WP_002887278.1 NZ_CP065831:c4806456-4806190 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT183452 NZ_CP087021:13495-13761 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGCTGGTTTTTTCGGATCAGGCCTGGGAAGATTATCAGTACTGGGTCAGCACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAATGCAAACGGACCCCCTTCAAAGGTTCCGGCTTGCCGGAACCTTTGAAGGGGGATTTGACAG
GCTGGTGGTCACGGCGAATTTCTCAGGAAGATCGAATGGTTTACCGGGTCAGTGGAACTGGCGACGGCCAAAGCTTAGAG
ATTGCGCAACTTCGGTTTCATTACTGA

Similar Proteins


Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

Loading, please wait
Source
ID
Structure
No matching records found


Antitoxin

Loading, please wait
Source
ID
Structure
PDB5ZGN
AlphaFold DBA0A0H3GLZ1

References