Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4179132..4179751 Replicon chromosome
Accession NZ_CP065831
Organism Klebsiella pneumoniae strain KpC11

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I8N76_RS20790 Protein ID WP_002892050.1
Coordinates 4179533..4179751 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I8N76_RS20785 Protein ID WP_002892066.1
Coordinates 4179132..4179506 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8N76_RS20775 4174284..4175477 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I8N76_RS20780 4175500..4178646 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
I8N76_RS20785 4179132..4179506 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I8N76_RS20790 4179533..4179751 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I8N76_RS20795 4179910..4180476 + 567 WP_002892030.1 maltose O-acetyltransferase -
I8N76_RS20800 4180448..4180588 - 141 WP_004147370.1 hypothetical protein -
I8N76_RS20805 4180609..4181079 + 471 WP_198091640.1 YlaC family protein -
I8N76_RS20810 4181054..4182505 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
I8N76_RS20815 4182606..4183304 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
I8N76_RS20820 4183301..4183441 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I8N76_RS20825 4183441..4183704 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T183451 WP_002892050.1 NZ_CP065831:4179533-4179751 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T183451 NZ_CP087020:c52982-52731 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT183451 WP_002892066.1 NZ_CP065831:4179132-4179506 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT183451 NZ_CP087020:c52734-52468 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References