Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 864374..865031 Replicon chromosome
Accession NZ_CP065831
Organism Klebsiella pneumoniae strain KpC11

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I8N76_RS04400 Protein ID WP_002916310.1
Coordinates 864621..865031 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I8N76_RS04395 Protein ID WP_002916312.1
Coordinates 864374..864640 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8N76_RS04370 859530..860963 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
I8N76_RS04375 861082..861810 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I8N76_RS04380 861860..862171 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
I8N76_RS04385 862335..862994 + 660 WP_002916317.1 hemolysin III family protein -
I8N76_RS04390 863145..864128 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
I8N76_RS04395 864374..864640 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I8N76_RS04400 864621..865031 + 411 WP_002916310.1 protein YgfX Toxin
I8N76_RS04405 865038..865559 - 522 WP_004144730.1 flavodoxin FldB -
I8N76_RS04410 865660..866556 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I8N76_RS04415 866579..867292 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I8N76_RS04420 867298..869031 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T183438 WP_002916310.1 NZ_CP065831:864621-865031 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T183438 NZ_CP087006:76300-76722 [Pseudosulfitobacter pseudonitzschiae]
ATGATCATCCTCGATACGAATGTCATCTGCGAGCTGTTGCGCCCGACCCCGGAGCCCAGGATCGAGCAATGGCTGTCCGC
TCAAGATGGTCTAAACGTCTACCTGACCTCGATATCGGAGGCGGAGCTGCGCTATGGCCTCGCGAACATGGGGAACGGCA
AGCGCCGCGCTGCGCTGATTGACGCCGTAGACCGCATCCTGCGCGAGGACCTCGCCGGGCGCATTCTGCCCTTCGACAGC
GACGCCGCGCAGGCATACGCCTCTATCGCCGCCACTCGTCGCGACGCCGGGCGACCGATTGCCCAGGCCGATTGCCAGAT
CGCATCCATTGCCCACGCCTGTGGCGCCACCGTCGCCACACGCAATACGCCCGACTTCGAGGGTTGCGAGATTGACCTGA
TCAACCCCTGGACAACCGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT183438 WP_002916312.1 NZ_CP065831:864374-864640 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT183438 NZ_CP087006:76048-76296 [Pseudosulfitobacter pseudonitzschiae]
ATGGCAAGCATTACGATCCGGAACCTTGACGATGACGTGAAGCGGCGCCTTCGCATCCGAGCGGCCGAGCATGGCCGTTC
GATGGAAGAGGAGGCGCGAGAGATCCTGCGCCAAGTCGTTGGCGACGCGAAGCCCAACCATGATCTTGCCGCGGCGATCC
GTGCGCGGGTTGGACCCTTGGGTGGCGTTGAACTTGACCTTCCGCAGCGTGAAGCCATGCATGAGCCGCCCACATTCGAC
CGAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References