Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3876729..3877348 Replicon chromosome
Accession NZ_CP065825
Organism Klebsiella pneumoniae strain KpPF25

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I8N74_RS18965 Protein ID WP_002892050.1
Coordinates 3877130..3877348 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I8N74_RS18960 Protein ID WP_002892066.1
Coordinates 3876729..3877103 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8N74_RS18950 3871881..3873074 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I8N74_RS18955 3873097..3876243 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
I8N74_RS18960 3876729..3877103 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I8N74_RS18965 3877130..3877348 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I8N74_RS18970 3877507..3878073 + 567 WP_002892030.1 maltose O-acetyltransferase -
I8N74_RS18975 3878045..3878185 - 141 WP_004147370.1 hypothetical protein -
I8N74_RS18980 3878206..3878676 + 471 WP_002892026.1 YlaC family protein -
I8N74_RS18985 3878651..3880102 - 1452 WP_023302231.1 PLP-dependent aminotransferase family protein -
I8N74_RS18990 3880203..3880901 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
I8N74_RS18995 3880898..3881038 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I8N74_RS19000 3881038..3881301 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T183429 WP_002892050.1 NZ_CP065825:3877130-3877348 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T183429 NZ_CP086997:c24278-23856 [Pseudosulfitobacter pseudonitzschiae]
ATGATCATCCTCGATACGAATGTCATCTGCGAGCTGTTGCGCCCGACCCCGGAGCCCAGGATCGAGCAATGGCTGTCCGC
TCAAGATGGTCTAAACGTCTACCTGACCTCGATATCGGAGGCGGAGCTGCGCTATGGCCTCGCGAACATGGGGAACGGCA
AGCGCCGCGCTGCGCTGATTGACGCCGTAGACCGCATCCTGCGCGAGGACCTCGCCGGGCGCATTCTGCCCTTCGACAGC
GACGCCGCGCAGGCATACGCCTCTATCGCCGCCACTCGTCGCGACGCCGGGCGACCGATTGCCCAGGCCGATTGCCAGAT
CGCATCCATTGCCCACGCCTGTGGCGCCACCGTCGCCACACGCAATACGCCCGACTTCGAGGGTTGCGAGATTGACCTGA
TCAACCCCTGGACAACCGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT183429 WP_002892066.1 NZ_CP065825:3876729-3877103 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT183429 NZ_CP086997:c24530-24282 [Pseudosulfitobacter pseudonitzschiae]
ATGGCAAGCATTACGATCCGGAACCTTGACGATGACGTGAAGCGGCGCCTTCGCATCCGAGCGGCCGAGCATGGCCGTTC
GATGGAAGAGGAGGCGCGAGAGATCCTGCGCCAAGTCGTTGGCGACGCGAAGCCCAACCATGATCTTGCCGCGGCGATCC
GTGCGCGGGTTGGACCCTTGGGTGGCGTTGAACTTGACCTTCCGCAGCGTGAAGCCATGCATGAGCCGCCCACATTCGAC
CGAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References