183419

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 786091..786748 Replicon chromosome
Accession NZ_CP065825
Organism Klebsiella pneumoniae strain KpPF25

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I8N74_RS03915 Protein ID WP_002916310.1
Coordinates 786338..786748 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I8N74_RS03910 Protein ID WP_002916312.1
Coordinates 786091..786357 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8N74_RS03885 781247..782680 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
I8N74_RS03890 782799..783527 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I8N74_RS03895 783577..783888 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
I8N74_RS03900 784052..784711 + 660 WP_002916317.1 hemolysin III family protein -
I8N74_RS03905 784862..785845 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
I8N74_RS03910 786091..786357 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I8N74_RS03915 786338..786748 + 411 WP_002916310.1 protein YgfX Toxin
I8N74_RS03920 786755..787276 - 522 WP_004144730.1 flavodoxin FldB -
I8N74_RS03925 787377..788273 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I8N74_RS03930 788296..789009 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I8N74_RS03935 789015..790748 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T183419 WP_002916310.1 NZ_CP065825:786338-786748 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T183419 NZ_CP086987:c77373-77098 [Pseudosulfitobacter pseudonitzschiae]
GTGCCTGACCTTGAATGGAAGGCATTGGCGGTCGCGGACCTGATGGCGATTGTTGACTATATCTCGGATGACAATCCCGA
TGCCGCAATTTCCCTGATGGATGACATTCAAGACAAGGTGCTTGGCCTTCTGACGCATCCCAAATCCGGCCGCCCCGGTA
GGGTGAACGACACGCGAGAGCTGGTGATCCGGCCCAACTATATCGTCGTCTATGCTGAAAACACGGCGGCGGTCACCATT
CTGCGCGTTCTTCATGCGGTGCAGATGTGGCCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT183419 WP_002916312.1 NZ_CP065825:786091-786357 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT183419 NZ_CP086987:c77659-77366 [Pseudosulfitobacter pseudonitzschiae]
ATGTCCGCTCAAACCTCGATGATTCATGTTCGTGTAGATGATCAGCTCAAGGCAAAGGCCACGGATGCCCTGTCCGGTGT
CGGCCTGACGTTGTCGGACGCCGTGCGCATCCTGCTGACCCGCGTGGCAGCAGAGGGTGGCTTGCCCGCAGGGTTGACGG
CAAATCCTGACGCCTACGATGCCTGGTTCCGCGCCAAGGTACAGGACGCATTGGCCGACGCAGCACCGGCCAAGCCGCAC
GATCAGGTGATGCGAGACGCGCGCGCCTTGATCGACGGCAAGCGCGGTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References