Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 5399596..5400101 Replicon chromosome
Accession NZ_CP065824
Organism Pseudomonas tolaasii strain Pt11

Toxin (Protein)


Gene name relE Uniprot ID A0A7Y8AS85
Locus tag I7845_RS24070 Protein ID WP_016971094.1
Coordinates 5399847..5400101 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7Y8ARW5
Locus tag I7845_RS24065 Protein ID WP_016971095.1
Coordinates 5399596..5399850 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7845_RS24045 (I7845_24045) 5395067..5396080 + 1014 WP_026082903.1 sensor domain-containing diguanylate cyclase -
I7845_RS24050 (I7845_24050) 5396081..5397109 - 1029 WP_177006515.1 amino acid ABC transporter substrate-binding protein -
I7845_RS24055 (I7845_24055) 5397254..5398147 + 894 WP_016971097.1 LysR substrate-binding domain-containing protein -
I7845_RS24060 (I7845_24060) 5398237..5399487 + 1251 WP_218819600.1 aspartate aminotransferase family protein -
I7845_RS24065 (I7845_24065) 5399596..5399850 + 255 WP_016971095.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
I7845_RS24070 (I7845_24070) 5399847..5400101 + 255 WP_016971094.1 Txe/YoeB family addiction module toxin Toxin
I7845_RS24075 (I7845_24075) 5400300..5401016 + 717 WP_016971093.1 hypothetical protein -
I7845_RS24080 (I7845_24080) 5401066..5402265 - 1200 WP_218819601.1 MFS transporter -
I7845_RS24085 (I7845_24085) 5402409..5403107 - 699 WP_177038983.1 LuxR family transcriptional regulator -
I7845_RS24090 (I7845_24090) 5403175..5404266 - 1092 WP_218819602.1 pyridoxal phosphate-dependent aminotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10079.60 Da        Isoelectric Point: 7.2754

>T183416 WP_016971094.1 NZ_CP065824:5399847-5400101 [Pseudomonas tolaasii]
MKILFTPEGWDDYLWFQQNDKTGLKRINLLIKAIQRDPFEGVGKPEPLKHNLSGFWSRRITAEHRLVYGIEDDEVQILMC
RYHY

Download         Length: 255 bp

>T183416 NZ_CP086985:92814-93236 [Pseudosulfitobacter pseudonitzschiae]
ATGATCATCCTCGATACGAATGTCATCTGCGAGCTGTTGCGCCCGACCCCGGAGCCCAGGATCGAGCAATGGCTGTCCGC
TCAAGATGGTCTAAACGTCTACCTGACCTCGATATCGGAGGCGGAGCTGCGCTATGGCCTCGCGAACATGGGGAACGGCA
AGCGCCGCGCTGCGCTGATTGACGCCGTAGACCGCATCCTGCGCGAGGACCTCGCCGGGCGCATTCTGCCCTTCGACAGC
GACGCCGCGCAGGCATACGCCTCTATCGCCGCCACTCGTCGCGACGCCGGGCGACCGATTGCCCAGGCCGATTGCCAGAT
CGCATCCATTGCCCACGCCTGTGGCGCCACCGTCGCCACACGCAATACGCCCGACTTCGAGGGTTGCGAGATTGACCTGA
TCAACCCCTGGACAACCGAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9508.90 Da        Isoelectric Point: 7.0140

>AT183416 WP_016971095.1 NZ_CP065824:5399596-5399850 [Pseudomonas tolaasii]
METINYTNARAHLAETMDRVNEDRIPLLLTRQKGEPVVMISLSEFNALEETAYLLRSPKNAERLINSVNSLRAGKAKPRG
LIEE

Download         Length: 255 bp

>AT183416 NZ_CP086985:92562-92810 [Pseudosulfitobacter pseudonitzschiae]
ATGGCAAGCATTACGATCCGGAACCTTGACGATGACGTGAAGCGGCGCCTTCGCATCCGAGCGGCCGAGCATGGCCGTTC
GATGGAAGAGGAGGCGCGAGAGATCCTGCGCCAAGTCGTTGGCGACGCGAAGCCCAACCATGATCTTGCCGCGGCGATCC
GTGCGCGGGTTGGACCCTTGGGTGGCGTTGAACTTGACCTTCCGCAGCGTGAAGCCATGCATGAGCCGCCCACATTCGAC
CGAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y8AS85

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y8ARW5

References