Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 3803225..3803838 Replicon chromosome
Accession NZ_CP065824
Organism Pseudomonas tolaasii strain Pt11

Toxin (Protein)


Gene name hicA Uniprot ID A0A7Y8AWJ7
Locus tag I7845_RS16525 Protein ID WP_017255853.1
Coordinates 3803225..3803476 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Y8ATU8
Locus tag I7845_RS16530 Protein ID WP_016974512.1
Coordinates 3803473..3803838 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7845_RS16525 (I7845_16525) 3803225..3803476 + 252 WP_017255853.1 type II toxin-antitoxin system HicA family toxin Toxin
I7845_RS16530 (I7845_16530) 3803473..3803838 + 366 WP_016974512.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I7845_RS16535 (I7845_16535) 3803839..3805011 - 1173 WP_016974513.1 MFS transporter -
I7845_RS16540 (I7845_16540) 3805153..3805734 + 582 WP_218819151.1 TetR/AcrR family transcriptional regulator -
I7845_RS16545 (I7845_16545) 3805803..3806768 + 966 WP_218819152.1 GlxA family transcriptional regulator -
I7845_RS16550 (I7845_16550) 3806838..3807299 + 462 WP_016974515.1 DUF3225 domain-containing protein -
I7845_RS16555 (I7845_16555) 3807300..3808655 - 1356 WP_026083054.1 MATE family efflux transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9408.04 Da        Isoelectric Point: 10.0469

>T183414 WP_017255853.1 NZ_CP065824:3803225-3803476 [Pseudomonas tolaasii]
VSKNEKLLAKLLNAQMAFTWPELVTLLLRLGYTQIEGAGSRVKFDIGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

>T183414 NZ_CP086982:c165878-165612 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13044.79 Da        Isoelectric Point: 6.3214

>AT183414 WP_016974512.1 NZ_CP065824:3803473-3803838 [Pseudomonas tolaasii]
VNNQLKHNGYIGSIEASLEDDCLFGKVLFIKALVSYEGKTVAELDAAFREAVDDYLATCMSLGQAPEKPCKGSFNVRVGH
DLHLAAALEATRKKVTLNDLTRQALSEFLQHHSVASSPAAG

Download         Length: 366 bp

>AT183414 NZ_CP086982:c166126-165875 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y8AWJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y8ATU8

References