Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1919248..1919852 Replicon chromosome
Accession NZ_CP065824
Organism Pseudomonas tolaasii strain Pt11

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag I7845_RS08715 Protein ID WP_218820239.1
Coordinates 1919248..1919436 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A2T4FRT1
Locus tag I7845_RS08720 Protein ID WP_016978509.1
Coordinates 1919448..1919852 (+) Length 135 a.a.

Genomic Context

I7845_RS08690I7845_RS08695I7845_RS08700I7845_RS08705I7845_RS08710I7845_RS08715I7845_RS08720I7845_RS08730I7845_RS08725I7845_RS08735I7845_RS08740
Location: 1915021..1915830 (810 bp)
Type: Others
Protein ID: WP_165448264.1
Location: 1915827..1916549 (723 bp)
Type: Others
Protein ID: WP_080519880.1
Location: 1916539..1917684 (1146 bp)
Type: Others
Protein ID: WP_177038239.1
Location: 1917684..1918256 (573 bp)
Type: Others
Protein ID: WP_177038238.1
Location: 1918247..1918996 (750 bp)
Type: Others
Protein ID: WP_177006963.1
Location: 1919248..1919436 (189 bp)
Type: Toxin
Protein ID: WP_218820239.1
Location: 1919448..1919852 (405 bp)
Type: Antitoxin
Protein ID: WP_016978509.1
Location: 1921298..1921912 (615 bp)
Type: Others
Protein ID: WP_016972132.1
Location: 1919923..1921119 (1197 bp)
Type: Others
Protein ID: WP_017255988.1
Location: 1922029..1923033 (1005 bp)
Type: Others
Protein ID: WP_016972133.1
Location: 1923139..1923963 (825 bp)
Type: Others
Protein ID: WP_177006964.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I7845_RS08690 (I7845_08690)1915021..1915830+810WP_165448264.1phosphonate C-P lyase system protein PhnK-
I7845_RS08695 (I7845_08695)1915827..1916549+723WP_080519880.1phosphonate C-P lyase system protein PhnL-
I7845_RS08700 (I7845_08700)1916539..1917684+1146WP_177038239.1alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase-
I7845_RS08705 (I7845_08705)1917684..1918256+573WP_177038238.1phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN-
I7845_RS08710 (I7845_08710)1918247..1918996+750WP_177006963.1phosphonate metabolism protein PhnP-
I7845_RS08715 (I7845_08715)1919248..1919436+189WP_218820239.1type II toxin-antitoxin system HicA family toxinToxin
I7845_RS08720 (I7845_08720)1919448..1919852+405WP_016978509.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
I7845_RS08725 (I7845_08725)1919923..1921119-1197WP_017255988.1MFS transporter-
I7845_RS08730 (I7845_08730)1921298..1921912+615WP_016972132.1DUF5666 domain-containing protein-
I7845_RS08735 (I7845_08735)1922029..1923033-1005WP_016972133.1sulfate ABC transporter substrate-binding protein-
I7845_RS08740 (I7845_08740)1923139..1923963-825WP_177006964.1ion transporter-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7193.38 Da        Isoelectric Point: 10.8676

>T183412 WP_218820239.1 NZ_CP065824:1919248-1919436 [Pseudomonas tolaasii]
VQSRLLIKELQEAGWVLDRVTGSHHIFTHRYSPYTIPVPHPKKDLPLGTVRSIRKRAGLFEF

Download         Length: 189 bp

>T183412 NZ_CP086980:23994-24389 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCGTTGAGTTCGCGGACACGAATGTCGTTCTTTACCTGCTCGACGACGGCCCAAAGGCCGATCGCGCCGAGGTCAT
CCTGGGGCAGGGGCCCCGGATCAGCGTTCAGGTTCTAAACGAGTCACTGGTGAACTGCCGCCGCAAAGCTGGCCTCGGTT
GGGAGGAAGCAGCGGCCTTTCTCGAAGGCGTGCGCGCCTTGTGTCCCGTCGAAGATCTCACCGTGCAGACCCATGACGTC
GGCCGCGCTTTGGCGGAACGCTACGGCTTCTCGATCTACGACGCGATGATCGTGGCCAGCGCTTTGGTTGCGGGGTGTAC
CACGCTGTGGAGCGAGGACATGCAAGATGGCCTGCTGGTGGAAGGCCAGCTTCGCATCGTCAACCCCTTTGCATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14701.68 Da        Isoelectric Point: 4.6000

>AT183412 WP_016978509.1 NZ_CP065824:1919448-1919852 [Pseudomonas tolaasii]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGGPIPMPTSVANHHAHEDYAGMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Download         Length: 405 bp

>AT183412 NZ_CP086980:23777-24004 [Pseudosulfitobacter pseudonitzschiae]
ATGCAGGTCGCAAAATGGGGTAACTCGCTGGCCGTCCGTTTGCCCGCGGAGCTCGTCCGAGAGCTTGGTCTCAAGGAGGG
TGATCAGATCGACCTGGTCAAGGACGACGGTCGGGTCAGAGTCCGTCGCCTTGCTCGTGCGGATGAGGTACTTACCGGCC
TGCGCCGCTTCCGGGGCAAGTTGTCCGCAGCAGAACGTCTGAGCCGCGACGACGCACATGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2T4FRT1

References