Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1626189..1626705 Replicon chromosome
Accession NZ_CP065824
Organism Pseudomonas tolaasii strain Pt11

Toxin (Protein)


Gene name relE Uniprot ID A0A7Y8APP2
Locus tag I7845_RS07305 Protein ID WP_016971342.1
Coordinates 1626189..1626476 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7Y8AQQ9
Locus tag I7845_RS07310 Protein ID WP_026083362.1
Coordinates 1626466..1626705 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7845_RS07275 (I7845_07275) 1621578..1622138 - 561 WP_003189463.1 glycine cleavage system protein R -
I7845_RS07280 (I7845_07280) 1622412..1623290 + 879 WP_177005941.1 4-hydroxy-tetrahydrodipicolinate synthase -
I7845_RS07285 (I7845_07285) 1623308..1624423 + 1116 WP_016971339.1 outer membrane protein assembly factor BamC -
I7845_RS07290 (I7845_07290) 1624428..1625186 + 759 WP_016971340.1 MBL fold metallo-hydrolase -
I7845_RS07295 (I7845_07295) 1625214..1625927 + 714 WP_016971341.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
I7845_RS07305 (I7845_07305) 1626189..1626476 - 288 WP_016971342.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I7845_RS07310 (I7845_07310) 1626466..1626705 - 240 WP_026083362.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I7845_RS07315 (I7845_07315) 1626893..1628119 - 1227 WP_080519989.1 MFS transporter -
I7845_RS07320 (I7845_07320) 1628588..1629136 + 549 WP_177038874.1 cytochrome b -
I7845_RS07325 (I7845_07325) 1629240..1629731 + 492 WP_086004068.1 hypothetical protein -
I7845_RS07330 (I7845_07330) 1629792..1630289 + 498 WP_016971348.1 RNA polymerase sigma factor -
I7845_RS07335 (I7845_07335) 1630286..1631053 + 768 WP_218820175.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11257.03 Da        Isoelectric Point: 10.0720

>T183411 WP_016971342.1 NZ_CP065824:c1626476-1626189 [Pseudomonas tolaasii]
MTYSLDFDARALKEWQKLGDTVRQQLKKKLVEILKNPRVETNRLHGLPDCYKIKLRSSGYRLVYQVIDQEITVFVVAVDK
RERDQVYQKASERLS

Download         Length: 288 bp

>T183411 NZ_CP086979:3811755-3812018 [Pseudosulfitobacter pseudonitzschiae]
ATGAAGTTCGAGTATGACCCTGACAAGAGTGCCGGGAACAAGGCCAAGCACGGCATCGACTTCGATGAAGCGCAAGCGCT
TTGGGAAGACCCGTGGCTGTTGGAGGCTCCCGCTCGAACAGATGACGAGCCGCGCTTTTTTGCAATAGGCATGATCAAGG
AACGGCATTGGTCAGCAGTTTGCACCTATCGCGGTGATATTATTCGGATCATCTCGGTGCGCCGCGCCAGAAAACAGGAG
ATTGAGCACTATGAAAGCACGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8959.37 Da        Isoelectric Point: 4.5742

>AT183411 WP_026083362.1 NZ_CP065824:c1626705-1626466 [Pseudomonas tolaasii]
MASINIRIDDDLKARAYLELEKLGVTPSELMRQALQYVADRGQLPFKPVLMTEDDEALMATVRERLASPQRVKVSIDDL

Download         Length: 240 bp

>AT183411 NZ_CP086979:3812005-3812220 [Pseudosulfitobacter pseudonitzschiae]
ATGAAAGCACGTGAGTTCGATCAAAAATTTGACACAGGTGAGAACGTCAGCGATCTTGTGGACTGGTCCAAAGCTAGGCG
GACGAATACCCAGACGAAGCGAGTCAATGTGGATTTTCCGTCGTGGGTCGTTTCTGGTTTGGATCAGAAGGCAAAGCAGC
TCGGCGTTACTCGTCAGTCGCTCATCAAACTCTGGATCGCCGAGCGGCTCCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y8APP2

Antitoxin

Source ID Structure
AlphaFold DB A0A7Y8AQQ9

References