Detailed information of TA system TA183409

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 388597..389047
• Replicon: chromosome
• Accession: NZ_CP065824
• Organism: Pseudomonas tolaasii strain Pt11

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I7845_RS01650
• Protein ID: WP_017254018.1
• Coordinates: 388778..389047 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7Y8DRR7
• Locus tag: I7845_RS01645
• Protein ID: WP_016972238.1
• Coordinates: 388597..388788 (+)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I7845_RS01625 (I7845_01625)	384136..384909	-	774	WP_010213906.1	ABC transporter ATP-binding protein	-
I7845_RS01630 (I7845_01630)	385464..386855	+	1392	WP_016972235.1	GABA permease	-
I7845_RS01635 (I7845_01635)	386976..387389	-	414	WP_218819905.1	hypothetical protein	-
I7845_RS01640 (I7845_01640)	387462..388415	-	954	WP_016972237.1	alpha/beta fold hydrolase	-
I7845_RS01645 (I7845_01645)	388597..388788	+	192	WP_016972238.1	hypothetical protein	Antitoxin
I7845_RS01650 (I7845_01650)	388778..389047	+	270	WP_017254018.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I7845_RS01655 (I7845_01655)	389123..390088	+	966	WP_218819906.1	arsenic resistance protein	-
I7845_RS01660 (I7845_01660)	390177..391784	+	1608	WP_218819907.1	glycosyltransferase family 39 protein	-
I7845_RS01665 (I7845_01665)	391796..392470	-	675	WP_016972242.1	hypothetical protein	-
I7845_RS01675 (I7845_01675)	392805..393077	-	273	WP_016972243.1	oxidative damage protection protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10343.88 Da
• Isoelectric Point: 5.1327

>T183409 WP_017254018.1 NZ_CP065824:388778-389047 [Pseudomonas tolaasii]
MRVEWRPEARAELRAILEYIIERNVAAASDLNEAIEEATTALPLHPYLYRLGKVSGTREIVVHPDYLVVYRVADWIEILT
VLHARQEYP

Nucleotide

• Length: 270 bp

>T183409 NZ_CP086977:74927-75349 [Pseudosulfitobacter pseudonitzschiae]
ATGATCATCCTCGATACGAATGTCATCTGCGAGCTGTTGCGCCCGACCCCGGAGCCCAGGATCGAGCAATGGCTGTCCGC
TCAAGATGGTCTAAACGTCTACCTGACCTCGATATCGGAGGCGGAGCTGCGCTATGGCCTCGCGAACATGGGGAACGGCA
AGCGCCGCGCTGCGCTGATTGACGCCGTAGACCGCATCCTGCGCGAGGACCTCGCCGGGCGCATTCTGCCCTTCGACAGC
GACGCCGCGCAGGCATACGCCTCTATCGCCGCCACTCGTCGCGACGCCGGGCGACCGATTGCCCAGGCCGATTGCCAGAT
CGCATCCATTGCCCACGCCTGTGGCGCCACCGTCGCCACACGCAATACGCCCGACTTCGAGGGTTGCGAGATTGACCTGA
TCAACCCCTGGACAACCGAATGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7319.14 Da
• Isoelectric Point: 4.5535

>AT183409 WP_016972238.1 NZ_CP065824:388597-388788 [Pseudomonas tolaasii]
MSTPLSPIVSEFETQEQADSYDRWFRAKVQASIDDPRPSIPHDQVMAEMRALLEARRKERDEG

Nucleotide

• Length: 192 bp

>AT183409 NZ_CP086977:74675-74923 [Pseudosulfitobacter pseudonitzschiae]
ATGGCAAGCATTACGATCCGGAACCTTGACGATGACGTGAAGCGGCGCCTTCGCATCCGAGCGGCCGAGCATGGCCGTTC
GATGGAAGAGGAGGCGCGAGAGATCCTGCGCCAAGTCGTTGGCGACGCGAAGCCCAACCATGATCTTGCCGCGGCGATCC
GTGCGCGGGTTGGACCCTTGGGTGGCGTTGAACTTGACCTTCCGCAGCGTGAAGCCATGCATGAGCCGCCCACATTCGAC
CGAGCCTAA

Structures

Antitoxin

• AlphaFold DB: A0A7Y8DRR7