Detailed information of TA system TA183408

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 488263..488916
• Replicon: chromosome
• Accession: NZ_CP065820
• Organism: Acinetobacter seifertii strain S21

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: I8T81_RS02390
• Protein ID: WP_198072038.1
• Coordinates: 488527..488916 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N8SCE2
• Locus tag: I8T81_RS02385
• Protein ID: WP_002049719.1
• Coordinates: 488263..488520 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I8T81_RS02365	483776..484783	+	1008	WP_004705386.1	DNA-directed RNA polymerase subunit alpha	-
I8T81_RS02370	484802..485179	+	378	WP_002049717.1	50S ribosomal protein L17	-
I8T81_RS02375	485361..486851	+	1491	WP_004705389.1	NAD(P)/FAD-dependent oxidoreductase	-
I8T81_RS02380	486901..488073	-	1173	WP_198072737.1	acyl-CoA dehydrogenase family protein	-
I8T81_RS02385	488263..488520	+	258	WP_002049719.1	succinate dehydrogenase assembly factor 2	Antitoxin
I8T81_RS02390	488527..488916	+	390	WP_198072038.1	hypothetical protein	Toxin
I8T81_RS02395	489685..490770	+	1086	WP_019457778.1	hypothetical protein	-
I8T81_RS02400	490855..491421	+	567	WP_004705397.1	rhombosortase	-
I8T81_RS02405	491609..493804	+	2196	WP_019457776.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15634.80 Da
• Isoelectric Point: 10.0222

>T183408 WP_198072038.1 NZ_CP065820:488527-488916 [Acinetobacter seifertii]
MINQLNFKLKYSRFSIIFQFFIGLSLAALFYQLIPILWWLVAICLLFISFIFFLKRPQLVQIAYLDQKLWSLSFHLEQTI
SRVEILKIIDYQIFIVVYFKGDRTLTSVIWFDQMSLSQWKQLKALEKFY

Nucleotide

• Length: 390 bp

>T183408 NZ_CP086975:19590-19985 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCGTTGAGTTCGCGGACACGAATGTCGTTCTTTACCTGCTCGACGACGGCCCAAAGGCCGATCGCGCCGAGGTCAT
CCTGGGGCAGGGGCCCCGGATCAGCGTTCAGGTTCTAAACGAGTCACTGGTGAACTGCCGCCGCAAAGCTGGCCTCGGTT
GGGAGGAAGCAGCGGCCTTTCTCGAAGGCGTGCGCGCCTTGTGTCCCGTCGAAGATCTCACCGTGCAGACCCATGACGTC
GGCCGCGCTTTGGCGGAACGCTACGGCTTCTCGATCTACGACGCGATGATCGTGGCCAGCGCTTTGGTTGCGGGGTGTAC
CACGCTGTGGAGCGAGGACATGCAAGATGGCCTGCTGGTGGAAGGCCAGCTTCGCATCGTCAACCCCTTTGCATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10278.71 Da
• Isoelectric Point: 4.7620

>AT183408 WP_002049719.1 NZ_CP065820:488263-488520 [Acinetobacter seifertii]
MSEEMTLEERKVVYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIHKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT183408 NZ_CP086975:19373-19600 [Pseudosulfitobacter pseudonitzschiae]
ATGCAGGTCGCAAAATGGGGTAACTCGCTGGCCGTCCGTTTGCCCGCGGAGCTCGTCCGAGAGCTTGGTCTCAAGGAGGG
TGATCAGATCGACCTGGTCAAGGACGACGGTCGGGTCAGAGTCCGTCGCCTTGCTCGTGCGGATGAGGTACTTACCGGCC
TGCGCCGCTTCCGGGGCAAGTTGTCCGCAGCAGAACGTCTGAGCCGCGACGACGCACATGAGCGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A0Q1QI86