Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1530574..1531380 Replicon chromosome
Accession NZ_CP065797
Organism Staphylococcus saprophyticus strain GDY8P168P

Toxin (Protein)


Gene name tsbT Uniprot ID Q49YQ0
Locus tag I7831_RS07630 Protein ID WP_011302805.1
Coordinates 1531195..1531380 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A380HJZ2
Locus tag I7831_RS07625 Protein ID WP_002482876.1
Coordinates 1530574..1531173 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7831_RS07605 1526452..1527915 + 1464 WP_002482872.1 ABC transporter substrate-binding protein/permease -
I7831_RS07610 1527908..1528630 + 723 WP_002482873.1 amino acid ABC transporter ATP-binding protein -
I7831_RS07615 1528791..1529918 + 1128 WP_002482874.1 tRNA epoxyqueuosine(34) reductase QueG -
I7831_RS07620 1529923..1530393 + 471 WP_002482875.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
I7831_RS07625 1530574..1531173 + 600 WP_002482876.1 glucosamine-6-phosphate isomerase Antitoxin
I7831_RS07630 1531195..1531380 + 186 WP_011302805.1 hypothetical protein Toxin
I7831_RS07635 1531537..1531953 + 417 WP_011302806.1 hypothetical protein -
I7831_RS07640 1532331..1533716 + 1386 WP_002482879.1 class II fumarate hydratase -
I7831_RS07645 1533919..1534746 - 828 WP_115338456.1 RluA family pseudouridine synthase -
I7831_RS07650 1534931..1536046 + 1116 WP_194375754.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7056.51 Da        Isoelectric Point: 3.8237

>T183407 WP_011302805.1 NZ_CP065797:1531195-1531380 [Staphylococcus saprophyticus]
MSLDKNQNNLHRDELESENAMVDDLEDVVELGKEMEQISEENDEDKLDKSHDPAVRSDLNE

Download         Length: 186 bp

>T183407 NZ_CP086974:300384-300710 [Pseudosulfitobacter pseudonitzschiae]
GTGAGGCGTGGTGAGCTGGTGACGGTCGCCCTTCAGGGCGACCACGGCAAGCCGCGTCCCGCGCTTGTGATCCAATCCGA
CCGGTTTCCGGACACCGCCACCACGACCGTCCTTCTGGTTACATCCACCTTGGTGGATGCGCCGTTGATTCGGCTGACGG
TCGAACCCTCTGCGGAGAACGGGTTGCGTATGCGATCACAGATCATGATCGACAAAGCCGTGACAGTTCGAACGGACAAG
CTGGGGAAAGCTTTCGGTCAGCTGGACGATACCGCCATGATCGAGGTGAACCGGGCACTAGCACTGTTTTTAGGAGTGGC
GGGGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22294.12 Da        Isoelectric Point: 4.9719

>AT183407 WP_002482876.1 NZ_CP065797:1530574-1531173 [Staphylococcus saprophyticus]
MAMNFKVLENEQVVAEYAADILRKQFNNNPTTIAGVHLSSDNAPVLDELKKNVDKHAVDFSQINILDYDNNKSYFEALGV
PEGQIFNVSFGEDTESFIKDKIKTKENKGKLITQVLSIDTNGKLDVSVNQGLFSSREVILIITGSNKKEVVHKLYEENGK
TSFEPSDLKAHRMVNVILDEAAAEGLPEDVRHYFTARFA

Download         Length: 600 bp

>AT183407 NZ_CP086974:300169-300387 [Pseudosulfitobacter pseudonitzschiae]
ATGCCAACCTCTGTTTCTCACCGTGTCCAGAAGCGTCGCGATGCCTTGCGTGCCGCTGGTTTGCGCCCCGTCCAGATTTG
GGTGCCGGATACCCGCCGCCCCGGTTTCGAGGCTGAGTGCCGCCGCCAGGCTGCAATTGTAGCCAAGGCCGATCGCGCAG
ATGATACTCTGAACGATTTCCTGGATGCCTCCCTGGTCGATGTGGATGACTGGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HKL3

Antitoxin

Source ID Structure
AlphaFold DB A0A380HJZ2

References