Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1393092..1393621 Replicon chromosome
Accession NZ_CP065797
Organism Staphylococcus saprophyticus strain GDY8P168P

Toxin (Protein)


Gene name mazF Uniprot ID A0A7Y8QER5
Locus tag I7831_RS06825 Protein ID WP_041080775.1
Coordinates 1393259..1393621 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A380HJK7
Locus tag I7831_RS06820 Protein ID WP_037538046.1
Coordinates 1393092..1393262 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7831_RS06795 1388823..1389302 + 480 WP_002482747.1 PH domain-containing protein -
I7831_RS06800 1389295..1390833 + 1539 WP_198065333.1 PH domain-containing protein -
I7831_RS06805 1390826..1391326 + 501 WP_041080777.1 PH domain-containing protein -
I7831_RS06810 1391390..1391740 + 351 WP_002482750.1 holo-ACP synthase -
I7831_RS06815 1391856..1393004 + 1149 WP_198065242.1 alanine racemase -
I7831_RS06820 1393092..1393262 + 171 WP_037538046.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
I7831_RS06825 1393259..1393621 + 363 WP_041080775.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I7831_RS06830 1393958..1394959 + 1002 WP_041080774.1 PP2C family protein-serine/threonine phosphatase -
I7831_RS06835 1395038..1395364 + 327 WP_011302705.1 anti-sigma factor antagonist -
I7831_RS06840 1395366..1395848 + 483 WP_002482755.1 anti-sigma B factor RsbW -
I7831_RS06845 1395823..1396593 + 771 WP_194376098.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13511.70 Da        Isoelectric Point: 10.3173

>T183406 WP_041080775.1 NZ_CP065797:1393259-1393621 [Staphylococcus saprophyticus]
MMRRGDVYLADLSPVQGSEQGGIRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKSKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDKKMKEVNNAIDISLGLHNIRSHKS

Download         Length: 363 bp

>T183406 NZ_CP086974:c114987-114565 [Pseudosulfitobacter pseudonitzschiae]
ATGATCATCCTCGATACGAATGTCATCTGCGAGCTGTTGCGCCCGACCCCGGAGCCCAGGATCGAGCAATGGCTGTCCGC
TCAAGATGGTCTAAACGTCTACCTGACCTCGATATCGGAGGCGGAGCTGCGCTATGGCCTCGCGAACATGGGGAACGGCA
AGCGCCGCGCTGCGCTGATTGACGCCGTAGACCGCATCCTGCGCGAGGACCTCGCCGGGCGCATTCTGCCCTTCGACAGC
GACGCCGCGCAGGCATACGCCTCTATCGCCGCCACTCGTCGCGACGCCGGGCGACCGATTGCCCAGGCCGATTGCCAGAT
CGCATCCATTGCCCACGCCTGTGGCGCCACCGTCGCCACACGCAATACGCCCGACTTCGAGGGTTGCGAGATTGACCTGA
TCAACCCCTGGACAACCGAATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6304.97 Da        Isoelectric Point: 4.0121

>AT183406 WP_037538046.1 NZ_CP065797:1393092-1393262 [Staphylococcus saprophyticus]
MASFNQSRIHSIEQLLKEGYSQMADLNLSLAAEAFPFECEACDCNEVYISSKNNNE

Download         Length: 171 bp

>AT183406 NZ_CP086974:c115239-114991 [Pseudosulfitobacter pseudonitzschiae]
ATGGCAAGCATTACGATCCGGAACCTTGACGATGACGTGAAGCGGCGCCTTCGCATCCGAGCGGCCGAGCATGGCCGTTC
GATGGAAGAGGAGGCGCGAGAGATCCTGCGCCAAGTCGTTGGCGACGCGAAGCCCAACCATGATCTTGCCGCGGCGATCC
GTGCGCGGGTTGGACCCTTGGGTGGCGTTGAACTTGACCTTCCGCAGCGTGAAGCCATGCATGAGCCGCCCACATTCGAC
CGAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y8QER5

Antitoxin

Source ID Structure
AlphaFold DB A0A380HJK7

References