Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1381426..1381940 Replicon chromosome
Accession NZ_CP065797
Organism Staphylococcus saprophyticus strain GDY8P168P

Toxin (Protein)


Gene name TsdT Uniprot ID A0A380HLI4
Locus tag I7831_RS06765 Protein ID WP_002482741.1
Coordinates 1381734..1381940 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q49Z35
Locus tag I7831_RS06760 Protein ID WP_002482740.1
Coordinates 1381426..1381719 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7831_RS06735 1376588..1377379 + 792 WP_002482735.1 hydroxyethylthiazole kinase -
I7831_RS06740 1377379..1378017 + 639 WP_002482736.1 thiamine phosphate synthase -
I7831_RS06745 1378105..1378974 + 870 WP_002482737.1 membrane protein insertase YidC -
I7831_RS06750 1379056..1379664 - 609 WP_176720937.1 HD domain-containing protein -
I7831_RS06755 1379799..1381283 - 1485 WP_011302692.1 cardiolipin synthase -
I7831_RS06760 1381426..1381719 + 294 WP_002482740.1 copper-sensing transcriptional repressor CsoR Antitoxin
I7831_RS06765 1381734..1381940 + 207 WP_002482741.1 hypothetical protein Toxin
I7831_RS06770 1382151..1382291 + 141 WP_002482742.1 hypothetical protein -
I7831_RS06775 1382595..1383788 - 1194 WP_041080781.1 rod shape-determining protein RodA -
I7831_RS06780 1384037..1385107 + 1071 WP_002482744.1 D-alanine--D-alanine ligase -
I7831_RS06785 1385120..1386475 + 1356 WP_002482745.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 8052.33 Da        Isoelectric Point: 4.3776

>T183405 WP_002482741.1 NZ_CP065797:1381734-1381940 [Staphylococcus saprophyticus]
MQSKVIYIAELYNEKQKLQIEERLMKLYGVFKVSIDIEEGAIFVDFETPANLNNLEKEVYDLGYKIIY

Download         Length: 207 bp

>T183405 NZ_CP086973:92776-93042 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11221.90 Da        Isoelectric Point: 6.3282

>AT183405 WP_002482740.1 NZ_CP065797:1381426-1381719 [Staphylococcus saprophyticus]
MTEIQKAHHSEEIKANLKSRLNRIEGQVKAINRMVEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVEQGHE
QEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT183405 NZ_CP086973:92528-92779 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCGAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380HLI4

Antitoxin

Source ID Structure
AlphaFold DB A0A380HKS9

References