Detailed information of TA system TA183402

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1545353..1546103
• Replicon: chromosome
• Accession: NZ_CP065792
• Organism: Mammaliicoccus sciuri strain GDK8D6P

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: I7827_RS07950
• Protein ID: WP_101494413.1
• Coordinates: 1545996..1546103 (+)
• Length: 36 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A657XLL6
• Locus tag: I7827_RS07945
• Protein ID: WP_025904800.1
• Coordinates: 1545353..1545952 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I7827_RS07920	1540877..1541638	+	762	WP_049320866.1	acetylglutamate kinase	-
I7827_RS07925	1542287..1543414	+	1128	WP_048539836.1	tRNA epoxyqueuosine(34) reductase QueG	-
I7827_RS07930	1543418..1543891	+	474	WP_198054218.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
I7827_RS07935	1543926..1544066	-	141	WP_162841915.1	hypothetical protein	-
I7827_RS07940	1544153..1545304	+	1152	WP_179926527.1	N-acetylglucosamine-6-phosphate deacetylase	-
I7827_RS07945	1545353..1545952	+	600	WP_025904800.1	glucosamine-6-phosphate isomerase	Antitoxin
I7827_RS07950	1545996..1546103	+	108	WP_101494413.1	hypothetical protein	Toxin
I7827_RS07955	1546258..1547646	+	1389	WP_065381353.1	class II fumarate hydratase	-
I7827_RS07960	1547736..1549262	+	1527	WP_198054219.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (134-195)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4130.43 Da
• Isoelectric Point: 3.7615

>T183402 WP_101494413.1 NZ_CP065792:1545996-1546103 [Mammaliicoccus sciuri]
MVQDLEDVKELGKEMEQISEQNDEAFEEKKSEQES

Nucleotide

• Length: 108 bp

>T183402 NZ_CP086971:c2524159-2523905 [Pseudosulfitobacter pseudonitzschiae]
ATGAACAGCAAGCAGCGGAAAACACTCAAGGCGATTTTCACCGATCCGGTGTCTGGCACAATCGAATGGGTCAGGATCGA
AAGTCTCCTTGTCGCGGCTGGCGCTGAAACCATCGAAGGCAACGGCTCGCGCGTTCGCTTTGTTAAGGACGGCGTGGTTG
GATCGTTCCACCGCCCGCACCCTGACAAAGAGGCAAAGCGCTATCAGGTTAGAGACGCCCGCGCCTTCCTAACGCAGATT
GGAGTAACGCCATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22291.16 Da
• Isoelectric Point: 4.8551

>AT183402 WP_025904800.1 NZ_CP065792:1545353-1545952 [Mammaliicoccus sciuri]
MALNFKVFETKDIAARYAADVVRKQFNSDSTSVVGVHLEAEQTSFFDELLDDVKKNPVNFSQIHILDFDGKEDYYTELGV
PAKQVLKTDVGSDVEAFIKEKVNTDKKKNKLMLDVVTLTEDSRTGLDYDQAIHPAREVIVLVTGKEKAKAVSQLYQEPAN
GSVESAKLKQHRMVTVVLDNEAAQGLPEDVRSYFSIQFS

Nucleotide

• Length: 600 bp

>AT183402 NZ_CP086971:c2523908-2523579 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCACCATGACTTTCAAAGGCTATCAGGCCCGTGTGGAGTTCGATCCAGAGGACGAGATTTTCTTCGGTAGAATTGC
CGGGATAAACGATGTGGTTGGCTTCCACGGCGAAAGCGTTGCCGAGCTTAAGAGTGCCTTTCATGAAGCCGTTGATGATT
ATCTTGAAACCTGCAAGGCGGCTGGCAAGAAGCCCCAGAAGCCGTATTCTGGCAAGGTGATGTTTCGAGTCGCTCCTGAA
ACCCACAGGCGCATCGCAGTTGCAGCTGAACTTTCCGGCAAGAGCCTGAACCAGTGGGCAGAAGAAAAGCTAGAGGCTGC
TGCCCACTAA

Structures

Antitoxin

• AlphaFold DB: A0A657XLL6