183401

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1361458..1361997 Replicon chromosome
Accession NZ_CP065792
Organism Mammaliicoccus sciuri strain GDK8D6P

Toxin (Protein)


Gene name mazF Uniprot ID A0A418JBZ2
Locus tag I7827_RS06900 Protein ID WP_048540867.1
Coordinates 1361626..1361997 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A657XHG2
Locus tag I7827_RS06895 Protein ID WP_025904510.1
Coordinates 1361458..1361625 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I7827_RS06870 1357340..1357819 + 480 WP_058612364.1 PH domain-containing protein -
I7827_RS06875 1357809..1359329 + 1521 WP_058612363.1 PH domain-containing protein -
I7827_RS06880 1359319..1359783 + 465 WP_058612362.1 PH domain-containing protein -
I7827_RS06885 1359815..1360177 + 363 WP_058591084.1 holo-ACP synthase -
I7827_RS06890 1360225..1361373 + 1149 WP_070369140.1 alanine racemase -
I7827_RS06895 1361458..1361625 + 168 WP_025904510.1 hypothetical protein Antitoxin
I7827_RS06900 1361626..1361997 + 372 WP_048540867.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I7827_RS06905 1362094..1363098 + 1005 WP_048540866.1 PP2C family protein-serine/threonine phosphatase -
I7827_RS06910 1363203..1363526 + 324 WP_025904513.1 anti-sigma factor antagonist -
I7827_RS06915 1363531..1364007 + 477 WP_025904514.1 anti-sigma B factor RsbW -
I7827_RS06920 1363982..1364752 + 771 WP_037589755.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13653.83 Da        Isoelectric Point: 9.9193

>T183401 WP_048540867.1 NZ_CP065792:1361626-1361997 [Mammaliicoccus sciuri]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDIAIAISLNLTLQQKFDTLGNT

Download         Length: 372 bp

>T183401 NZ_CP086971:c545654-545391 [Pseudosulfitobacter pseudonitzschiae]
ATGAAGTTCGAGTATGACCCTGACAAGAGTGCCGGGAACAAGGCCAAGCACGGCATCGACTTCGATGAAGCGCAAGCGCT
TTGGGAAGACCCGTGGCTGTTGGAGGCTCCCGCTCGAACAGATGACGAGCCGCGCTTTTTTGCAATAGGCATGATCAAGG
AACGGCATTGGTCAGCAGTTTGCACCTATCGCGGTGATATTATTCGGATCATCTCGGTGCGCCGCGCCAGAAAACAGGAG
ATTGAGCACTATGAAAGCACGTGA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6136.65 Da        Isoelectric Point: 4.0121

>AT183401 WP_025904510.1 NZ_CP065792:1361458-1361625 [Mammaliicoccus sciuri]
MTSLTQNRTQSLEQTLKEGYRSMADLNLSLASEAYYCECEACDSNESHIASQQGE

Download         Length: 168 bp

>AT183401 NZ_CP086971:c545404-545189 [Pseudosulfitobacter pseudonitzschiae]
ATGAAAGCACGTGAGTTCGATCAAAAATTTGACACAGGTGAGAACGTCAGCGATCTTGTGGACTGGTCCAAAGCTAGGCG
GACGAATACCCAGACGAAGCGAGTCAATGTGGATTTTCCGTCGTGGGTCGTTTCTGGTTTGGATCAGAAGGCAAAGCAGC
TCGGCGTTACTCGTCAGTCGCTCATCAAACTCTGGATCGCCGAGCGGCTCCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A418JBZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A657XHG2

References