Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
| Location | 1847706..1848399 | Replicon | chromosome |
| Accession | NZ_CP065784 | ||
| Organism | Enterococcus faecalis strain 18-243 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | S4BLV4 |
| Locus tag | I8F59_RS09230 | Protein ID | WP_002378467.1 |
| Coordinates | 1848055..1848399 (+) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | I8F59_RS09225 | Protein ID | WP_002364355.1 |
| Coordinates | 1847706..1848038 (+) | Length | 111 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I8F59_RS09180 (1843178) | 1843178..1843912 | - | 735 | WP_002378463.1 | ERF family protein | - |
| I8F59_RS09185 (1843905) | 1843905..1844222 | - | 318 | WP_002357007.1 | hypothetical protein | - |
| I8F59_RS09190 (1844442) | 1844442..1844996 | + | 555 | WP_002357006.1 | hypothetical protein | - |
| I8F59_RS15425 (1845423) | 1845423..1845617 | - | 195 | WP_244323659.1 | hypothetical protein | - |
| I8F59_RS09200 (1845654) | 1845654..1845863 | - | 210 | WP_002378465.1 | hypothetical protein | - |
| I8F59_RS09205 (1845918) | 1845918..1846106 | + | 189 | WP_002357001.1 | YegP family protein | - |
| I8F59_RS09210 (1846132) | 1846132..1846857 | - | 726 | WP_002378466.1 | phage regulatory protein | - |
| I8F59_RS09215 (1846896) | 1846896..1847207 | - | 312 | WP_002381719.1 | hypothetical protein | - |
| I8F59_RS09220 (1847218) | 1847218..1847394 | - | 177 | WP_002364354.1 | helix-turn-helix transcriptional regulator | - |
| I8F59_RS09225 (1847706) | 1847706..1848038 | + | 333 | WP_002364355.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| I8F59_RS09230 (1848055) | 1848055..1848399 | + | 345 | WP_002378467.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| I8F59_RS09235 (1848435) | 1848435..1849163 | + | 729 | WP_002378468.1 | potassium channel family protein | - |
| I8F59_RS09240 (1849263) | 1849263..1850411 | + | 1149 | WP_002378469.1 | site-specific integrase | - |
| I8F59_RS09245 (1850448) | 1850448..1850882 | - | 435 | Protein_1803 | competence type IV pilus minor pilin ComGD | - |
| I8F59_RS09250 (1850879) | 1850879..1851154 | - | 276 | WP_002356991.1 | competence type IV pilus major pilin ComGC | - |
| I8F59_RS09255 (1851154) | 1851154..1852200 | - | 1047 | WP_002401325.1 | competence type IV pilus assembly protein ComGB | - |
| I8F59_RS09260 (1852157) | 1852157..1853125 | - | 969 | WP_002401324.1 | competence type IV pilus ATPase ComGA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1811462..1871692 | 60230 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13712.62 Da Isoelectric Point: 5.5523
>T183347 WP_002378467.1 NZ_CP065784:1848055-1848399 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN
Download Length: 345 bp
>T183347 NZ_CP086917:c69237-68962 [Pseudosulfitobacter pseudonitzschiae]
GTGCCTGACCTTGAATGGAAGGCATTGGCGGTCGCGGACCTGATGGCGATTGTTGACTATATCTCGGATGACAATCCCGA
TGCCGCAATTTCCCTGATGGATGACATTCAAGACAAGGTGCTTGGCCTTCTGACGCATCCCAAATCCGGCCGCCCCGGTA
GGGTGAACGACACGCGAGAGCTGGTGATCCGGCCCAACTATATCGTCGTCTATGCTGAAAACACGGCGGCGGTCACCATT
CTGCGCGTTCTTCATGCGGTGCAGATGTGGCCCTGA
GTGCCTGACCTTGAATGGAAGGCATTGGCGGTCGCGGACCTGATGGCGATTGTTGACTATATCTCGGATGACAATCCCGA
TGCCGCAATTTCCCTGATGGATGACATTCAAGACAAGGTGCTTGGCCTTCTGACGCATCCCAAATCCGGCCGCCCCGGTA
GGGTGAACGACACGCGAGAGCTGGTGATCCGGCCCAACTATATCGTCGTCTATGCTGAAAACACGGCGGCGGTCACCATT
CTGCGCGTTCTTCATGCGGTGCAGATGTGGCCCTGA
Antitoxin
Download Length: 111 a.a. Molecular weight: 12691.16 Da Isoelectric Point: 4.6307
>AT183347 WP_002364355.1 NZ_CP065784:1847706-1848038 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
Download Length: 333 bp
>AT183347 NZ_CP086917:c69523-69230 [Pseudosulfitobacter pseudonitzschiae]
ATGTCCGCTCAAACCTCGATGATTCATGTTCGTGTAGATGATCAGCTCAAGGCAAAGGCCACGGATGCCCTGTCCGGTGT
CGGCCTGACGTTGTCGGACGCCGTGCGCATCCTGCTGACCCGCGTGGCAGCAGAGGGTGGCTTGCCCGCAGGGTTGACGG
CAAATCCTGACGCCTACGATGCCTGGTTCCGCGCCAAGGTACAGGACGCATTGGCCGACGCAGCACCGGCCAAGCCGCAC
GATCAGGTGATGCGAGACGCGCGCGCCTTGATCGACGGCAAGCGCGGTGCCTGA
ATGTCCGCTCAAACCTCGATGATTCATGTTCGTGTAGATGATCAGCTCAAGGCAAAGGCCACGGATGCCCTGTCCGGTGT
CGGCCTGACGTTGTCGGACGCCGTGCGCATCCTGCTGACCCGCGTGGCAGCAGAGGGTGGCTTGCCCGCAGGGTTGACGG
CAAATCCTGACGCCTACGATGCCTGGTTCCGCGCCAAGGTACAGGACGCATTGGCCGACGCAGCACCGGCCAAGCCGCAC
GATCAGGTGATGCGAGACGCGCGCGCCTTGATCGACGGCAAGCGCGGTGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|