183343

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 406234..406816 Replicon chromosome
Accession NZ_CP065784
Organism Enterococcus faecalis strain 18-243

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag I8F59_RS02065 Protein ID WP_002355414.1
Coordinates 406508..406816 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag I8F59_RS02060 Protein ID WP_002326825.1
Coordinates 406234..406506 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8F59_RS02030 (401515) 401515..402243 - 729 WP_002355404.1 GntR family transcriptional regulator -
I8F59_RS02035 (402420) 402420..403346 + 927 WP_002355406.1 hypothetical protein -
I8F59_RS02040 (403363) 403363..404646 + 1284 WP_002363033.1 PTS sugar transporter subunit IIC -
I8F59_RS02045 (404838) 404838..404960 + 123 Protein_378 topoisomerase -
I8F59_RS02050 (405035) 405035..405931 + 897 WP_002363034.1 ParA family protein -
I8F59_RS02055 (406008) 406008..406217 + 210 WP_002363035.1 peptide-binding protein -
I8F59_RS02060 (406234) 406234..406506 + 273 WP_002326825.1 antitoxin Antitoxin
I8F59_RS02065 (406508) 406508..406816 + 309 WP_002355414.1 zeta toxin family protein Toxin
I8F59_RS02070 (406896) 406896..407318 - 423 WP_080005963.1 tyrosine-type recombinase/integrase -
I8F59_RS02075 (407369) 407369..407869 - 501 WP_002363039.1 HAD family hydrolase -
I8F59_RS02080 (407874) 407874..408641 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
I8F59_RS02085 (409128) 409128..409553 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
I8F59_RS02090 (409570) 409570..410085 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
I8F59_RS02095 (410096) 410096..411028 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ClpL bsh / esp / psaA 374047..489040 114993


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T183343 WP_002355414.1 NZ_CP065784:406508-406816 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

>T183343 NZ_CP086912:108336-108731 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCGTTGAGTTCGCGGACACGAATGTCGTTCTTTACCTGCTCGACGACGGCCCAAAGGCCGATCGCGCCGAGGTCAT
CCTGGGGCAGGGGCCCCGGATCAGCGTTCAGGTTCTAAACGAGTCACTGGTGAACTGCCGCCGCAAAGCTGGCCTCGGTT
GGGAGGAAGCAGCGGCCTTTCTCGAAGGCGTGCGCGCCTTGTGTCCCGTCGAAGATCTCACCGTGCAGACCCATGACGTC
GGCCGCGCTTTGGCGGAACGCTACGGCTTCTCGATCTACGACGCGATGATCGTGGCCAGCGCTTTGGTTGCGGGGTGTAC
CACGCTGTGGAGCGAGGACATGCAAGATGGCCTGCTGGTGGAAGGCCAGCTTCGCATCGTCAACCCCTTTGCATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT183343 WP_002326825.1 NZ_CP065784:406234-406506 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp

>AT183343 NZ_CP086912:108119-108346 [Pseudosulfitobacter pseudonitzschiae]
ATGCAGGTCGCAAAATGGGGTAACTCGCTGGCCGTCCGTTTGCCCGCGGAGCTCGTCCGAGAGCTTGGTCTCAAGGAGGG
TGATCAGATCGACCTGGTCAAGGACGACGGTCGGGTCAGAGTCCGTCGCCTTGCTCGTGCGGATGAGGTACTTACCGGCC
TGCGCCGCTTCCGGGGCAAGTTGTCCGCAGCAGAACGTCTGAGCCGCGACGACGCACATGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References