Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 252431..252960 Replicon chromosome
Accession NZ_CP065777
Organism Enterococcus faecium strain 16-021

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag I8F57_RS01260 Protein ID WP_002296560.1
Coordinates 252694..252960 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag I8F57_RS01255 Protein ID WP_002296559.1
Coordinates 252431..252694 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8F57_RS01245 (I8F57_01245) 249805..251628 + 1824 WP_002294202.1 APC family permease -
I8F57_RS01250 (I8F57_01250) 251770..251955 - 186 WP_002296558.1 transcriptional regulator -
I8F57_RS01255 (I8F57_01255) 252431..252694 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I8F57_RS01260 (I8F57_01260) 252694..252960 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
I8F57_RS01265 (I8F57_01265) 253161..253649 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
I8F57_RS01270 (I8F57_01270) 254190..254843 - 654 WP_002323018.1 ABC transporter permease -
I8F57_RS01275 (I8F57_01275) 254858..255775 - 918 WP_002296564.1 osmoprotectant ABC transporter substrate-binding protein -
I8F57_RS01280 (I8F57_01280) 255772..256413 - 642 WP_002293405.1 ABC transporter permease -
I8F57_RS01285 (I8F57_01285) 256417..256998 - 582 Protein_255 CBS domain-containing protein -
I8F57_RS01290 (I8F57_01290) 257156..257560 + 405 WP_002287522.1 IS200/IS605-like element ISEfa4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T183338 WP_002296560.1 NZ_CP065777:252694-252960 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T183338 NZ_CP086908:c18190-17924 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGCTGGTTTTTTCGGATCAGGCCTGGGAAGATTATCAGTACTGGGTCAGCACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAATGCAAACGGACCCCCTTCAAAGGTTCCGGCTTGCCGGAACCTTTGAAGGGGGATTTGACAG
GCTGGTGGTCACGGCGAATTTCTCAGGAAGATCGAATGGTTTACCGGGTCAGTGGAACTGGCGACGGCCAAAGCTTAGAG
ATTGCGCAACTTCGGTTTCATTACTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT183338 WP_002296559.1 NZ_CP065777:252431-252694 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT183338 NZ_CP086908:c18438-18187 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTACTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCTATCCACGACAAGCAGGAAGT
TGTCGTGACGCGCAAGAAGGGCGAGTCCGTTGTGGTCGTGTCCTTGGACACTTGGAACGCCGTCAACGAGACTTTGCACC
TGTTGTCCACACCGAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGAGCGTGAG
CTGACCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References