Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 182945..183474 Replicon chromosome
Accession NZ_CP065752
Organism Enterococcus faecium strain 18-465

Toxin (Protein)


Gene name relE Uniprot ID A0A2D0BMD7
Locus tag I8F49_RS00920 Protein ID WP_002319468.1
Coordinates 183208..183474 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag I8F49_RS00915 Protein ID WP_002294199.1
Coordinates 182945..183208 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I8F49_RS00905 (I8F49_00900) 180320..182143 + 1824 WP_002294202.1 APC family permease -
I8F49_RS00910 (I8F49_00905) 182285..182470 - 186 WP_038811433.1 hypothetical protein -
I8F49_RS00915 (I8F49_00910) 182945..183208 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I8F49_RS00920 (I8F49_00915) 183208..183474 + 267 WP_002319468.1 Txe/YoeB family addiction module toxin Toxin
I8F49_RS00925 (I8F49_00920) 183675..184163 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
I8F49_RS00930 (I8F49_00925) 184705..185358 - 654 WP_002317081.1 ABC transporter permease -
I8F49_RS00935 (I8F49_00930) 185373..186290 - 918 WP_002319470.1 osmoprotectant ABC transporter substrate-binding protein -
I8F49_RS00940 (I8F49_00935) 186287..186928 - 642 WP_002293405.1 ABC transporter permease -
I8F49_RS00945 (I8F49_00940) 186932..188107 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.08 Da        Isoelectric Point: 9.9931

>T183325 WP_002319468.1 NZ_CP065752:183208-183474 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVAEI
YSAWTHYE

Download         Length: 267 bp

>T183325 NZ_CP086896:92527-92778 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT183325 WP_002294199.1 NZ_CP065752:182945-183208 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT183325 NZ_CP086896:92775-93041 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2D0BMD7

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References