Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 454399..455054 Replicon chromosome
Accession NZ_CP065751
Organism Moraxella osloensis strain FDAARGOS_870

Toxin (Protein)


Gene name vapC Uniprot ID A0A109WBT2
Locus tag I6G27_RS02065 Protein ID WP_062332881.1
Coordinates 454399..454800 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A378Q6B5
Locus tag I6G27_RS02070 Protein ID WP_062332879.1
Coordinates 454818..455054 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G27_RS02045 450144..450938 + 795 WP_062332890.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
I6G27_RS02050 451035..452393 - 1359 WP_062334846.1 amino-acid N-acetyltransferase -
I6G27_RS02055 452911..453444 + 534 WP_062332887.1 hypothetical protein -
I6G27_RS02060 453511..454395 - 885 WP_062332884.1 patatin-like phospholipase family protein -
I6G27_RS02065 454399..454800 - 402 WP_062332881.1 tRNA(fMet)-specific endonuclease VapC Toxin
I6G27_RS02070 454818..455054 - 237 WP_062332879.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6G27_RS02075 455346..457526 + 2181 WP_115304570.1 ATP-dependent DNA helicase RecG -
I6G27_RS02080 457749..457928 + 180 WP_036592470.1 hypothetical protein -
I6G27_RS02085 458387..460048 - 1662 WP_062332873.1 electron transfer flavoprotein-ubiquinone oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(9-55)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14941.02 Da        Isoelectric Point: 6.8695

>T183323 WP_062332881.1 NZ_CP065751:c454800-454399 [Moraxella osloensis]
MLTFMLDTNIAIHVIKQRPIAALNKFNQYAARICVSSITVAELYFGAENSQNLAKNLAQVDDFLSRLVILDYDSQAGSHY
GNIYADLTKKGNVISENDMHIAGHARSRGLILVTNNLREFERVEGLRLDNWVS

Download         Length: 402 bp

>T183323 NZ_CP086894:3812467-3812730 [Pseudosulfitobacter pseudonitzschiae]
ATGAAGTTCGAGTATGACCCTGACAAGAGTGCCGGGAACAAGGCCAAGCACGGCATCGACTTCGATGAAGCGCAAGCGCT
TTGGGAAGACCCGTGGCTGTTGGAGGCTCCCGCTCGAACAGATGACGAGCCGCGCTTTTTTGCAATAGGCATGATCAAGG
AACGGCATTGGTCAGCAGTTTGCACCTATCGCGGTGATATTATTCGGATCATCTCGGTGCGCCGCGCCAGAAAACAGGAG
ATTGAGCACTATGAAAGCACGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8982.15 Da        Isoelectric Point: 7.2032

>AT183323 WP_062332879.1 NZ_CP065751:c455054-454818 [Moraxella osloensis]
MTQASVFFNNRTQAVRLPADMRFADDIKHVHIRKVGNERILTPITNVWDSFFIAKDPVSDDFMAQRGNAPISQRESFD

Download         Length: 237 bp

>AT183323 NZ_CP086894:3812717-3812932 [Pseudosulfitobacter pseudonitzschiae]
ATGAAAGCACGTGAGTTCGATCAAAAATTTGACACAGGTGAGAACGTCAGCGATCTTGTGGACTGGTCCAAAGCTAGGCG
GACGAATACCCAGACGAAGCGAGTCAATGTGGATTTTCCGTCGTGGGTCGTTTCTGGTTTGGATCAGAAGGCAAAGCAGC
TCGGCGTTACTCGTCAGTCGCTCATCAAACTCTGGATCGCCGAGCGGCTCCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A109WBT2

Antitoxin

Source ID Structure
AlphaFold DB A0A378Q6B5

References