Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/couple_hipB(antitoxin)
Location 232916..233439 Replicon chromosome
Accession NZ_CP065751
Organism Moraxella osloensis strain FDAARGOS_870

Toxin (Protein)


Gene name hipA Uniprot ID A0A109WBX0
Locus tag I6G27_RS01015 Protein ID WP_062333327.1
Coordinates 232916..233137 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A378QGA6
Locus tag I6G27_RS01020 Protein ID WP_062333324.1
Coordinates 233134..233439 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G27_RS01010 229131..232694 + 3564 WP_082741489.1 DEAD/DEAH box helicase -
I6G27_RS01015 232916..233137 + 222 WP_062333327.1 hypothetical protein Toxin
I6G27_RS01020 233134..233439 + 306 WP_062333324.1 helix-turn-helix domain-containing protein Antitoxin
I6G27_RS01025 233536..233781 - 246 WP_062333322.1 hypothetical protein -
I6G27_RS01030 233988..235070 - 1083 WP_062333319.1 WYL domain-containing protein -
I6G27_RS01035 235087..235347 - 261 WP_062333316.1 hypothetical protein -
I6G27_RS01040 235328..235693 - 366 WP_082741438.1 metallophosphoesterase -
I6G27_RS01045 235842..237542 - 1701 WP_062333310.1 DUF262 domain-containing HNH endonuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-94)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8452.91 Da        Isoelectric Point: 4.9859

>T183322 WP_062333327.1 NZ_CP065751:232916-233137 [Moraxella osloensis]
MLFQGRYNFIAICESLSDLIEPSILLEELKQTAEKLVDLPNRLQQRGVSEKILLHPAIAFDYLPKRLQDWGLL

Download         Length: 222 bp

>T183322 NZ_CP086894:1833961-1834215 [Pseudosulfitobacter pseudonitzschiae]
ATGAACAGCAAGCAGCGGAAAACACTCAAGGCGATTTTCACCGATCCGGTGTCTGGCACAATCGAATGGGTCAGGATCGA
AAGTCTCCTTGTCGCGGCTGGCGCTGAAACCATCGAAGGCAACGGCTCGCGCGTTCGCTTTGTTAAGGACGGCGTGGTTG
GATCGTTCCACCGCCCGCACCCTGACAAAGAGGCAAAGCGCTATCAGGTTAGAGACGCCCGCGCCTTCCTAACGCAGATT
GGAGTAACGCCATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11455.08 Da        Isoelectric Point: 10.0912

>AT183322 WP_062333324.1 NZ_CP065751:233134-233439 [Moraxella osloensis]
MNNLLNRQRASDAAPDLQGLSRTQARDQVIEQFMQGELTQGELLKKLRIDILGVKQDAFATLVKFSRKTISDVENDNGNY
SVNTINQIFRPFGLVLKLGYR

Download         Length: 306 bp

>AT183322 NZ_CP086894:1834212-1834541 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCACCATGACTTTCAAAGGCTATCAGGCCCGTGTGGAGTTCGATCCAGAGGACGAGATTTTCTTCGGTAGAATTGC
CGGGATAAACGATGTGGTTGGCTTCCACGGCGAAAGCGTTGCCGAGCTTAAGAGTGCCTTTCATGAAGCCGTTGATGATT
ATCTTGAAACCTGCAAGGCGGCTGGCAAGAAGCCCCAGAAGCCGTATTCTGGCAAGGTGATGTTTCGAGTCGCTCCTGAA
ACCCACAGGCGCATCGCAGTTGCAGCTGAACTTTCCGGCAAGAGCCTGAACCAGTGGGCAGAAGAAAAGCTAGAGGCTGC
TGCCCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A109WBX0

Antitoxin

Source ID Structure
AlphaFold DB A0A378QGA6

References