Detailed information of TA system TA183317

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): rlegTA/AbiEii-AbiEi
• Location: 4742236..4743692
• Replicon: chromosome
• Accession: NZ_CP065748
• Organism: Delftia lacustris strain FDAARGOS_890

Toxin (Protein)

• Gene name: rlegT
• Uniprot ID: A0A7T3DDN2
• Locus tag: I6G47_RS22090
• Protein ID: WP_016447320.1
• Coordinates: 4742236..4743081 (-)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: rlegA
• Uniprot ID: -
• Locus tag: I6G47_RS22095
• Protein ID: WP_016447321.1
• Coordinates: 4743078..4743692 (-)
• Length: 205 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G47_RS22065	4737589..4738752	+	1164	WP_198129297.1	ABC transporter substrate-binding protein	-
I6G47_RS22070	4738803..4739675	+	873	WP_013799989.1	branched-chain amino acid ABC transporter permease	-
I6G47_RS22075	4739679..4740746	+	1068	WP_016447317.1	branched-chain amino acid ABC transporter permease	-
I6G47_RS22080	4740739..4741497	+	759	WP_016452268.1	ABC transporter ATP-binding protein	-
I6G47_RS22085	4741502..4742203	+	702	WP_034348629.1	ABC transporter ATP-binding protein	-
I6G47_RS22090	4742236..4743081	-	846	WP_016447320.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6G47_RS22095	4743078..4743692	-	615	WP_016447321.1	AbiEi antitoxin N-terminal domain-containing protein	Antitoxin
I6G47_RS22100	4743800..4744273	-	474	WP_016452266.1	hotdog fold thioesterase	-
I6G47_RS22105	4744412..4745926	-	1515	WP_016452265.1	acetyl-CoA hydrolase/transferase family protein	-
I6G47_RS22110	4746135..4747442	-	1308	WP_016452264.1	NCS2 family nucleobase:cation symporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (35-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (12-57)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 31001.64 Da
• Isoelectric Point: 7.2651

>T183317 WP_016447320.1 NZ_CP065748:c4743081-4742236 [Delftia lacustris]
MSRDIAASIRARLKQCADARRQDFNLTLTHYGLERLLYRLSISPHADSYLLKGALLFAIWYEQPHRPTRDADLLGFGLDD
VDSAVSAFREICGIAVDDGIAFDAASVRGTAIRKEAGYGGVRIDLRATLDGARITLQVDIGFGDAVTPSPQTIRYPVLLD
GLPAPQLRSYPKYTVVAEKLHAICLLGMANTRMKDYFDLWVLMTEGTLDPAELRRAMAATFERRQLALPAGLPAGLSDGF
SSDAAKQAQWAAFLKKNRLEALELAPVVARLREEFQQCGIF

Nucleotide

• Length: 846 bp

>T183317 NZ_CP086887:c49197-48922 [Pseudosulfitobacter pseudonitzschiae]
GTGCCTGACCTTGAATGGAAGGCATTGGCGGTCGCGGACCTGATGGCGATTGTTGACTATATCTCGGATGACAATCCCGA
TGCCGCAATTTCCCTGATGGATGACATTCAAGACAAGGTGCTTGGCCTTCTGACGCATCCCAAATCCGGCCGCCCCGGTA
GGGTGAACGACACGCGAGAGCTGGTGATCCGGCCCAACTATATCGTCGTCTATGCTGAAAACACGGCGGCGGTCACCATT
CTGCGCGTTCTTCATGCGGTGCAGATGTGGCCCTGA

Antitoxin

Protein

• Length: 205 a.a.
• Molecular weight: 21967.59 Da
• Isoelectric Point: 9.9117

>AT183317 WP_016447321.1 NZ_CP065748:c4743692-4743078 [Delftia lacustris]
MPAPGSALEQAVLALAEQRPLLRARDLAALGLPTMALSRLVAAGRLERVARGLYSLPGRPLSEHRSLAEVALRVPQGVVC
LLSALRVHGIGTQAPFEVWMAIPHHSPTPRIDQPALRAIRMSGAALSEGVETLQIDGVGVAVFNASKTVADCFKYRNKIG
LDVALEALRDGWAQRKLTADALWHYAAIDRVSNVMRPYLESIAA

Nucleotide

• Length: 615 bp

>AT183317 NZ_CP086887:c49483-49190 [Pseudosulfitobacter pseudonitzschiae]
ATGTCCGCTCAAACCTCGATGATTCATGTTCGTGTAGATGATCAGCTCAAGGCAAAGGCCACGGATGCCCTGTCCGGTGT
CGGCCTGACGTTGTCGGACGCCGTGCGCATCCTGCTGACCCGCGTGGCAGCAGAGGGTGGCTTGCCCGCAGGGTTGACGG
CAAATCCTGACGCCTACGATGCCTGGTTCCGCGCCAAGGTACAGGACGCATTGGCCGACGCAGCACCGGCCAAGCCGCAC
GATCAGGTGATGCGAGACGCGCGCGCCTTGATCGACGGCAAGCGCGGTGCCTGA

Structures

Toxin

• AlphaFold DB: A0A7T3DDN2