Detailed information of TA system TA183316

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 4253001..4254684
• Replicon: chromosome
• Accession: NZ_CP065748
• Organism: Delftia lacustris strain FDAARGOS_890

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: I6G47_RS19880
• Protein ID: WP_034348397.1
• Coordinates: 4253830..4254684 (-)
• Length: 285 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A072T3J4
• Locus tag: I6G47_RS19875
• Protein ID: WP_016449819.1
• Coordinates: 4253001..4253807 (-)
• Length: 269 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G47_RS19845	4248655..4249425	-	771	WP_012202888.1	SDR family oxidoreductase	-
I6G47_RS19850	4250080..4250355	+	276	WP_016452048.1	hypothetical protein	-
I6G47_RS19855	4250619..4250966	+	348	Protein_3917	type II toxin-antitoxin system RelE/ParE family toxin	-
I6G47_RS19860	4250963..4251271	+	309	WP_016452050.1	XRE family transcriptional regulator	-
I6G47_RS19865	4251284..4252045	-	762	WP_016452051.1	5'-methylthioadenosine/adenosylhomocysteine nucleosidase	-
I6G47_RS19870	4252149..4252946	-	798	WP_016452052.1	aspartate dehydrogenase	-
I6G47_RS19875	4253001..4253807	-	807	WP_016449819.1	IclR family transcriptional regulator	Antitoxin
I6G47_RS19880	4253830..4254684	-	855	WP_034348397.1	alpha/beta fold hydrolase	Toxin
I6G47_RS19885	4254834..4255364	-	531	WP_016449821.1	cupin domain-containing protein	-
I6G47_RS19890	4255564..4256760	-	1197	WP_016452054.1	MFS transporter	-
I6G47_RS19895	4256783..4257667	-	885	WP_016452055.1	NAD(P)-dependent oxidoreductase	-
I6G47_RS19900	4257804..4258394	-	591	WP_013804518.1	TetR/AcrR family transcriptional regulator	-
I6G47_RS19905	4258476..4258967	-	492	WP_016449824.1	Lrp/AsnC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (43-270)

Antitoxin

• Transcription regulator IclR, C-terminal (137-255)

Sequences

Toxin

Protein

• Length: 285 a.a.
• Molecular weight: 29506.90 Da
• Isoelectric Point: 7.3739

>T183316 WP_034348397.1 NZ_CP065748:c4254684-4253830 [Delftia lacustris]
MTPSVTACMEQRLQAQFPEHLIALPGGAQVAWREAGDTASDFAVVMLHGISSGAASWMDVALALAPRTRVLAWDAPGYGR
STPLAPAAPTGADYARVLDQSLQVLGVRRCLLVGHSLGALMGTPWAVQAGAGRVQQLVLISPAGGYGAPGMGEQQAKVRQ
GRLAALQEKGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAAGRLAMPVEVWVGEHDVV
TPPAACAAWAARLGARYVTLAAAGHASVVEQPADVAQRLATLLT

Nucleotide

• Length: 855 bp

>T183316 NZ_CP086886:3808623-3808886 [Pseudosulfitobacter pseudonitzschiae]
ATGAAGTTCGAGTATGACCCTGACAAGAGTGCCGGGAACAAGGCCAAGCACGGCATCGACTTCGATGAAGCGCAAGCGCT
TTGGGAAGACCCGTGGCTGTTGGAGGCTCCCGCTCGAACAGATGACGAGCCGCGCTTTTTTGCAATAGGCATGATCAAGG
AACGGCATTGGTCAGCAGTTTGCACCTATCGCGGTGATATTATTCGGATCATCTCGGTGCGCCGCGCCAGAAAACAGGAG
ATTGAGCACTATGAAAGCACGTGA

Antitoxin

Protein

• Length: 269 a.a.
• Molecular weight: 29047.08 Da
• Isoelectric Point: 5.3408

>AT183316 WP_016449819.1 NZ_CP065748:c4253807-4253001 [Delftia lacustris]
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLEGMGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQSLCDRLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDA
DQLRALFGGSELPQFSESTPRSVEQLLQLLQQDHERGYAMGEGFYEPGVSSIAAPVRDAQGRIVAGLGMAVAFTEIAPGR
MADWVEQVRAAADELAGHLRTQHPGFLR

Nucleotide

• Length: 807 bp

>AT183316 NZ_CP086886:3808873-3809088 [Pseudosulfitobacter pseudonitzschiae]
ATGAAAGCACGTGAGTTCGATCAAAAATTTGACACAGGTGAGAACGTCAGCGATCTTGTGGACTGGTCCAAAGCTAGGCG
GACGAATACCCAGACGAAGCGAGTCAATGTGGATTTTCCGTCGTGGGTCGTTTCTGGTTTGGATCAGAAGGCAAAGCAGC
TCGGCGTTACTCGTCAGTCGCTCATCAAACTCTGGATCGCCGAGCGGCTCCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A072T3J4