Detailed information of TA system TA183313

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 344350..345059
• Replicon: chromosome
• Accession: NZ_CP065748
• Organism: Delftia lacustris strain FDAARGOS_890

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: I6G47_RS01625
• Protein ID: WP_016453265.1
• Coordinates: 344350..344796 (-)
• Length: 149 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1D8IU58
• Locus tag: I6G47_RS01630
• Protein ID: WP_016453264.1
• Coordinates: 344793..345059 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G47_RS01605	339948..341162	+	1215	WP_016453268.1	ABC transporter permease	-
I6G47_RS01610	341164..342309	+	1146	WP_016453267.1	ABC transporter permease	-
I6G47_RS01615	342373..343002	-	630	WP_016453266.1	DUF4124 domain-containing protein	-
I6G47_RS01620	343081..344286	-	1206	WP_016448243.1	MFS transporter	-
I6G47_RS01625	344350..344796	-	447	WP_016453265.1	type II toxin-antitoxin system VapC family toxin	Toxin
I6G47_RS01630	344793..345059	-	267	WP_016453264.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
I6G47_RS01635	345084..346055	-	972	WP_016453263.1	LysR family transcriptional regulator	-
I6G47_RS01640	346132..347016	+	885	WP_191625570.1	amidohydrolase family protein	-
I6G47_RS01645	347043..348038	+	996	WP_016448238.1	tripartite tricarboxylate transporter substrate binding protein	-
I6G47_RS01650	348062..349693	-	1632	WP_016453261.1	gamma-glutamyltransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-133)

Antitoxin

• SpoVT-AbrB domain (8-54)

Sequences

Toxin

Protein

• Length: 149 a.a.
• Molecular weight: 15880.46 Da
• Isoelectric Point: 8.1045

>T183313 WP_016453265.1 NZ_CP065748:c344796-344350 [Delftia lacustris]
MTRYLLDTNIASHIIKGDIPAVREQLVRVPMHQIAVSAVTQAELMYGVAKRGHPAGLSLRVTGFLARVEVLPWTAQVADA
YGHLRAACEATGITLASMDMMIAAHALLLQQQAAQAGERSVLVTRDRVFSRIPEPGLAIADWTTGPAG

Nucleotide

• Length: 447 bp

>T183313 NZ_CP086884:77063-77485 [Pseudosulfitobacter pseudonitzschiae]
ATGATCATCCTCGATACGAATGTCATCTGCGAGCTGTTGCGCCCGACCCCGGAGCCCAGGATCGAGCAATGGCTGTCCGC
TCAAGATGGTCTAAACGTCTACCTGACCTCGATATCGGAGGCGGAGCTGCGCTATGGCCTCGCGAACATGGGGAACGGCA
AGCGCCGCGCTGCGCTGATTGACGCCGTAGACCGCATCCTGCGCGAGGACCTCGCCGGGCGCATTCTGCCCTTCGACAGC
GACGCCGCGCAGGCATACGCCTCTATCGCCGCCACTCGTCGCGACGCCGGGCGACCGATTGCCCAGGCCGATTGCCAGAT
CGCATCCATTGCCCACGCCTGTGGCGCCACCGTCGCCACACGCAATACGCCCGACTTCGAGGGTTGCGAGATTGACCTGA
TCAACCCCTGGACAACCGAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10046.05 Da
• Isoelectric Point: 4.3846

>AT183313 WP_016453264.1 NZ_CP065748:c345059-344793 [Delftia lacustris]
VTQTAKLFTTGRSQAVRLPYEFRFEEKEVYIRRDPVTGDVILSRRPDSWQEFFALDATTDVPADFMDTADRAQPESGRDP
FADEGSAR

Nucleotide

• Length: 267 bp

>AT183313 NZ_CP086884:76811-77059 [Pseudosulfitobacter pseudonitzschiae]
ATGGCAAGCATTACGATCCGGAACCTTGACGATGACGTGAAGCGGCGCCTTCGCATCCGAGCGGCCGAGCATGGCCGTTC
GATGGAAGAGGAGGCGCGAGAGATCCTGCGCCAAGTCGTTGGCGACGCGAAGCCCAACCATGATCTTGCCGCGGCGATCC
GTGCGCGGGTTGGACCCTTGGGTGGCGTTGAACTTGACCTTCCGCAGCGTGAAGCCATGCATGAGCCGCCCACATTCGAC
CGAGCCTAA

Structures

Antitoxin

• AlphaFold DB: A0A1D8IU58