Detailed information of TA system TA183312

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 5359186..5359659
• Replicon: chromosome
• Accession: NZ_CP065747
• Organism: Serratia plymuthica strain FDAARGOS_896

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I6G53_RS25140
• Protein ID: WP_063202450.1
• Coordinates: 5359186..5359461 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2X4TR66
• Locus tag: I6G53_RS25145
• Protein ID: WP_062869225.1
• Coordinates: 5359462..5359659 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G53_RS25125	5354231..5354608	-	378	WP_197928943.1	AprI/Inh family metalloprotease inhibitor	-
I6G53_RS25130	5354664..5356127	-	1464	WP_062869227.1	serralysin family metalloprotease	-
I6G53_RS25135	5356810..5359125	+	2316	WP_197928946.1	zinc/cadmium/mercury/lead-transporting ATPase	-
I6G53_RS25140	5359186..5359461	-	276	WP_063202450.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
I6G53_RS25145	5359462..5359659	-	198	WP_062869225.1	hypothetical protein	Antitoxin
I6G53_RS25150	5359720..5359965	-	246	WP_004950955.1	sulfurtransferase TusA	-
I6G53_RS25155	5360186..5360851	+	666	WP_006323048.1	7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter	-
I6G53_RS25160	5360894..5361328	+	435	WP_197928948.1	GNAT family N-acetyltransferase	-
I6G53_RS25165	5361409..5361972	+	564	WP_004950949.1	DcrB family lipoprotein	-
I6G53_RS25170	5362021..5363220	-	1200	WP_063202454.1	anaerobic glycerol-3-phosphate dehydrogenase subunit C	-
I6G53_RS25175	5363217..5364488	-	1272	WP_197931106.1	glycerol-3-phosphate dehydrogenase subunit GlpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10660.56 Da
• Isoelectric Point: 11.2606

>T183312 WP_063202450.1 NZ_CP065747:c5359461-5359186 [Serratia plymuthica]
MLVIEWSRSARQDLADILLFIANDNPRAARKMKVLISEAILPAAEHPHIFRRGRVDGTHEIIVHPNYLLIYQVVADRIRV
MRVLHARRRYP

Nucleotide

• Length: 276 bp

>T183312 NZ_CP086880:c90981-90586 [Pseudosulfitobacter pseudonitzschiae]
ATGAGCGTTGAGTTCGCGGACACGAATGTCGTTCTTTACCTGCTCGACGACGGCCCAAAGGCCGATCGCGCCGAGGTCAT
CCTGGGGCAGGGGCCCCGGATCAGCGTTCAGGTTCTAAACGAGTCACTGGTGAACTGCCGCCGCAAAGCTGGCCTCGGTT
GGGAGGAAGCAGCGGCCTTTCTCGAAGGCGTGCGCGCCTTGTGTCCCGTCGAAGATCTCACCGTGCAGACCCATGACGTC
GGCCGCGCTTTGGCGGAACGCTACGGCTTCTCGATCTACGACGCGATGATCGTGGCCAGCGCTTTGGTTGCGGGGTGTAC
CACGCTGTGGAGCGAGGACATGCAAGATGGCCTGCTGGTGGAAGGCCAGCTTCGCATCGTCAACCCCTTTGCATGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7580.65 Da
• Isoelectric Point: 4.4488

>AT183312 WP_062869225.1 NZ_CP065747:c5359659-5359462 [Serratia plymuthica]
MVILRSPVVSEYETQEQTEIYDRWFREKVREAMDDPLPGISHDEVMAEMDALIAVAEARKKTKQV

Nucleotide

• Length: 198 bp

>AT183312 NZ_CP086880:c91198-90971 [Pseudosulfitobacter pseudonitzschiae]
ATGCAGGTCGCAAAATGGGGTAACTCGCTGGCCGTCCGTTTGCCCGCGGAGCTCGTCCGAGAGCTTGGTCTCAAGGAGGG
TGATCAGATCGACCTGGTCAAGGACGACGGTCGGGTCAGAGTCCGTCGCCTTGCTCGTGCGGATGAGGTACTTACCGGCC
TGCGCCGCTTCCGGGGCAAGTTGTCCGCAGCAGAACGTCTGAGCCGCGACGACGCACATGAGCGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A2X4TR66