Detailed information of TA system TA183311

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 5063026..5064575
• Replicon: chromosome
• Accession: NZ_CP065747
• Organism: Serratia plymuthica strain FDAARGOS_896

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6G53_RS23635
• Protein ID: WP_197928780.1
• Coordinates: 5063026..5064324 (-)
• Length: 433 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6G53_RS23640
• Protein ID: WP_004953056.1
• Coordinates: 5064327..5064575 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G53_RS23625	5058608..5061577	-	2970	WP_197928776.1	ATP-binding protein	-
I6G53_RS23630	5061574..5062719	-	1146	WP_197928778.1	DNA cytosine methyltransferase	-
I6G53_RS23635	5063026..5064324	-	1299	WP_197928780.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6G53_RS23640	5064327..5064575	-	249	WP_004953056.1	helix-turn-helix domain-containing protein	Antitoxin
I6G53_RS23645	5064757..5065458	-	702	WP_197928782.1	hypothetical protein	-
I6G53_RS23650	5065533..5065886	-	354	WP_197928784.1	hypothetical protein	-
I6G53_RS23655	5065959..5066381	-	423	WP_197931092.1	hypothetical protein	-
I6G53_RS23660	5066393..5066773	-	381	WP_197928786.1	hypothetical protein	-
I6G53_RS23665	5066770..5067291	-	522	WP_063202080.1	hypothetical protein	-
I6G53_RS23670	5067719..5068012	-	294	WP_197928788.1	hypothetical protein	-
I6G53_RS23675	5068151..5068423	-	273	WP_197931094.1	hypothetical protein	-
I6G53_RS23680	5068472..5068609	-	138	WP_197931114.1	hypothetical protein	-
I6G53_RS23685	5068917..5069552	-	636	WP_013811336.1	carbonic anhydrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	5045407..5079929	34522

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 433 a.a.
• Molecular weight: 48185.20 Da
• Isoelectric Point: 6.0152

>T183311 WP_197928780.1 NZ_CP065747:c5064324-5063026 [Serratia plymuthica]
MEKLRVALNGTLVGTLEKHAGGAMSFVYHEEWLAQAGARAISLSLPLQPEPFRGDVVYNFFDNLLPDSELIRSRLQARFR
TATKQPFDLLSSIGSDCVGAIQLYPEHADVAPVKQVNAVPVSDEEIEQLLLGYREAPLGMVAGTDDFRISLAGAQEKTAL
LWFGNQWCRPQGSTPTSHIIKLPIGHIAHNNLDLSESCENEWLCLRIAEQFGLPVAQAELARFGEQKALIVERFDRRWAR
DNSWLIRLPQEDFCQALGIAPALKYEADGGPGIAAAMQLLMGSQQPLLDRDTFFKSQIVFWMLAAIDGHAKNFSLFIEQE
TAYRMTPLYDVLSGYPFMHARGIAPQKAKMAMAVLGQSRHYRWSQILPRHFISTARAVGYSEEKTLQVMAELKAQTEQAI
ANVEAMLPDEFPRSVSDAIFSGVRRQAERLVG

Nucleotide

• Length: 1299 bp

>T183311 NZ_CP086879:131788-132054 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9263.60 Da
• Isoelectric Point: 10.4887

>AT183311 WP_004953056.1 NZ_CP065747:c5064575-5064327 [Serratia plymuthica]
MKITSAKMLAHALRNERKKRNQSQSKTADSIGLKQATVSAFENNPDGTRLETLFKLLAALDLELQVTPRGKPVDPKTWDQ
EW

Nucleotide

• Length: 249 bp

>AT183311 NZ_CP086879:131540-131791 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA