Detailed information of TA system TA183310

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 4672594..4673150
• Replicon: chromosome
• Accession: NZ_CP065747
• Organism: Serratia plymuthica strain FDAARGOS_896

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A2X4UAE5
• Locus tag: I6G53_RS21820
• Protein ID: WP_063202630.1
• Coordinates: 4672860..4673150 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: I6G53_RS21815
• Protein ID: WP_166728990.1
• Coordinates: 4672594..4672872 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G53_RS21790	4667935..4668774	-	840	WP_006323781.1	MurR/RpiR family transcriptional regulator	-
I6G53_RS21795	4668919..4670505	+	1587	WP_063202668.1	gamma-glutamyltransferase	-
I6G53_RS21800	4670530..4670721	+	192	WP_006322394.1	oxalurate catabolism protein HpxX	-
I6G53_RS21805	4670718..4672118	+	1401	WP_197912129.1	AtzE family amidohydrolase	-
I6G53_RS21810	4672122..4672508	+	387	WP_004949013.1	oxalurate catabolism protein HpxZ	-
I6G53_RS21815	4672594..4672872	+	279	WP_166728990.1	CopG family ribbon-helix-helix protein	Antitoxin
I6G53_RS21820	4672860..4673150	+	291	WP_063202630.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6G53_RS21825	4673160..4674044	-	885	WP_197928540.1	siderophore-interacting protein	-
I6G53_RS21830	4674050..4675273	-	1224	WP_197928542.1	MFS transporter	-
I6G53_RS21835	4675411..4677156	+	1746	WP_197928544.1	IucA/IucC family siderophore biosynthesis protein	-
I6G53_RS21840	4677153..4678103	+	951	WP_197928546.1	acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-93)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10904.65 Da
• Isoelectric Point: 9.5469

>T183310 WP_063202630.1 NZ_CP065747:4672860-4673150 [Serratia plymuthica]
VPQLIWTPAALLDVQQLYRFLAEKDLNSAKRAVATIRNCIKIIAHQPHIGRPAKDMAPEFREWPIDFGNSGYLVLYRFNG
VTAVILAIRHQSETGY

Nucleotide

• Length: 291 bp

>T183310 NZ_CP086879:131540-131791 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTATTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCGATCCACGACAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAGGAGAGTCCGTCGTGGTCGTATCCTTGGAAACCTGGAACGCCGTAAATGAGACGCTGCACC
TCCTGTCCACACCAAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGTGCGTGAG
CTGACCGAGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10627.68 Da
• Isoelectric Point: 4.9323

>AT183310 WP_166728990.1 NZ_CP065747:4672594-4672872 [Serratia plymuthica]
MATATSIKIDDELKQRVQHIAAAHQRSAHWIMREAIREYVEREEKREAVRNDALQAWETYQANGKHLTQDEADGWLSDLE
KGDDTEIPGCHN

Nucleotide

• Length: 279 bp

>AT183310 NZ_CP086879:131788-132054 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGTTGGTTTTTTCCGATCAGGCTTGGGAAGACTATCAGTACTGGGTCAACACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAGTGCAGGCGGACCCCTTTCAAAGGAACCGGCAAGCCGGAACCTTTGAAGGGCGATCTGACCG
GCTGGTGGTCACGGCGGATTTCTCAGGAAGATCGAATGGTCTACCGGGTTAGTGGAACTGGCGACGGCCAAAGCCTAGAG
ATTGCACAACTGCGGTTTCATTACTGA

Structures

Toxin

• AlphaFold DB: A0A2X4UAE5