183309

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4429745..4430367 Replicon chromosome
Accession NZ_CP065747
Organism Serratia plymuthica strain FDAARGOS_896

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag I6G53_RS20670 Protein ID WP_006322256.1
Coordinates 4430164..4430367 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag I6G53_RS20665 Protein ID WP_004949348.1
Coordinates 4429745..4430113 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G53_RS20630 4425786..4426040 + 255 WP_004949355.1 type B 50S ribosomal protein L31 -
I6G53_RS20635 4426053..4426193 + 141 WP_013811779.1 type B 50S ribosomal protein L36 -
I6G53_RS20640 4426309..4427187 - 879 WP_197928332.1 metal ABC transporter substrate-binding protein -
I6G53_RS20645 4427213..4428070 - 858 WP_062869871.1 metal ABC transporter permease -
I6G53_RS20650 4428067..4428780 - 714 WP_197928334.1 ABC transporter ATP-binding protein -
I6G53_RS20655 4428777..4428926 - 150 WP_197928336.1 hypothetical protein -
I6G53_RS20660 4429232..4429585 + 354 WP_063198033.1 hypothetical protein -
I6G53_RS20665 4429745..4430113 + 369 WP_004949348.1 Hha toxicity modulator TomB Antitoxin
I6G53_RS20670 4430164..4430367 + 204 WP_006322256.1 hemolysin expression modulator Hha Toxin
I6G53_RS20675 4430607..4431143 - 537 WP_006323971.1 cytochrome b/b6 domain-containing protein -
I6G53_RS20680 4431204..4432625 - 1422 WP_062869867.1 N-acetylglucosamine-binding protein GbpA -
I6G53_RS20685 4432905..4433279 + 375 WP_063198035.1 type II secretion system pilot lipoprotein GspS -
I6G53_RS20690 4433276..4434106 - 831 WP_073972022.1 A24 family peptidase -
I6G53_RS20695 4434139..4434600 - 462 WP_197928346.1 type II secretion system protein M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4429745..4446061 16316


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T183309 WP_006322256.1 NZ_CP065747:4430164-4430367 [Serratia plymuthica]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T183309 NZ_CP086878:32959-33225 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGCTGGTTTTTTCGGATCAGGCCTGGGAAGATTATCAGTACTGGGTCAGCACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAATGCAAACGGACCCCCTTCAAAGGTTCCGGCTTGCCGGAACCTTTGAAGGGGGATTTGACAG
GCTGGTGGTCACGGCGAATTTCTCAGGAAGATCGAATGGTTTACCGGGTCAGTGGAACTGGCGACGGCCAAAGCTTAGAG
ATTGCGCAACTTCGGTTTCATTACTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT183309 WP_004949348.1 NZ_CP065747:4429745-4430113 [Serratia plymuthica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp

>AT183309 NZ_CP086878:32711-32962 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTACTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCTATCCACGACAAGCAGGAAGT
TGTCGTGACGCGCAAGAAGGGCGAGTCCGTTGTGGTCGTGTCCTTGGACACTTGGAACGCCGTCAACGAGACTTTGCACC
TGTTGTCCACACCGAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGAGCGTGAG
CTGACCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1KM53

Antitoxin

Source ID Structure
AlphaFold DB S4YKH5

References