Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3909366..3909922 Replicon chromosome
Accession NZ_CP065747
Organism Serratia plymuthica strain FDAARGOS_896

Toxin (Protein)


Gene name ccdB Uniprot ID A0A7U4DW07
Locus tag I6G53_RS18045 Protein ID WP_013812173.1
Coordinates 3909366..3909683 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2X4U7C9
Locus tag I6G53_RS18050 Protein ID WP_063199959.1
Coordinates 3909686..3909922 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G53_RS18025 3905137..3906294 - 1158 WP_197927875.1 YbfB/YjiJ family MFS transporter -
I6G53_RS18030 3906402..3907319 + 918 WP_063199956.1 LysR family transcriptional regulator -
I6G53_RS18035 3907348..3908475 + 1128 WP_062870249.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
I6G53_RS18040 3908490..3909332 + 843 WP_004942338.1 S-formylglutathione hydrolase -
I6G53_RS18045 3909366..3909683 - 318 WP_013812173.1 CcdB family protein Toxin
I6G53_RS18050 3909686..3909922 - 237 WP_063199959.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
I6G53_RS18055 3910067..3910975 - 909 WP_013812171.1 glutathione ABC transporter permease GsiD -
I6G53_RS18060 3910985..3911905 - 921 WP_062870247.1 glutathione ABC transporter permease GsiC -
I6G53_RS18065 3911958..3913496 - 1539 WP_004942332.1 glutathione ABC transporter substrate-binding protein GsiB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11972.92 Da        Isoelectric Point: 5.8267

>T183308 WP_013812173.1 NZ_CP065747:c3909683-3909366 [Serratia plymuthica]
MQFTVYANTGKSAVYPLLLDVTNDIIEQLNRRVMIPLLPIEKYPASTRPERLNPLVRLVDDNEYAVMTHEMASIPVRILG
AEFCDASQYRTKVKAAIDFLFDGIR

Download         Length: 318 bp

>T183308 NZ_CP086878:32711-32962 [Pseudosulfitobacter pseudonitzschiae]
ATGGATGTTATGACCTACTCAGACGCACGAGCTCAACTGAAGGGCGTCATGGATCGAGCTATCCACGACAAGCAGGAAGT
TGTCGTGACGCGCAAGAAGGGCGAGTCCGTTGTGGTCGTGTCCTTGGACACTTGGAACGCCGTCAACGAGACTTTGCACC
TGTTGTCCACACCGAAAAACGCATCCCGCTTGCGCGCGTCGATCGCGCAACTCGATGCTGGAACTGGCGAAGAGCGTGAG
CTGACCGAGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9152.24 Da        Isoelectric Point: 6.7189

>AT183308 WP_063199959.1 NZ_CP065747:c3909922-3909686 [Serratia plymuthica]
MPVKQRTTQSVTMAVERSLLSRAREAGINLSTTLNTALDAELRQHEMRKWKEENREAIDALNRFHEEHGCFSDEYRTF

Download         Length: 237 bp

>AT183308 NZ_CP086878:32959-33225 [Pseudosulfitobacter pseudonitzschiae]
GTGAAGCTGGTTTTTTCGGATCAGGCCTGGGAAGATTATCAGTACTGGGTCAGCACCAACGACAAGGTACGTGACCGGAT
CAACGAGCTGATCAAGCAATGCAAACGGACCCCCTTCAAAGGTTCCGGCTTGCCGGAACCTTTGAAGGGGGATTTGACAG
GCTGGTGGTCACGGCGAATTTCTCAGGAAGATCGAATGGTTTACCGGGTCAGTGGAACTGGCGACGGCCAAAGCTTAGAG
ATTGCGCAACTTCGGTTTCATTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4DW07

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4U7C9

References